The nitrogen–nitrogen bond is a core feature of diverse functional groups like hydrazines,
nitrosamines, diazos, and pyrazoles. Such functional groups are found in> 300 known …

Covering: up to 2014 In this review we investigate the use of complex ester fragment
couplings within natural product total synthesis campaigns. We first outline the different …

Vinyl epoxides are molecules with a rich chemistry because of the strained oxirane, already
a reactive moiety on its own, in proximity with a carbon− carbon double bond. The chemistry …

Tubulin-targeted chemotherapy has proven to be a successful and wide spectrum strategy
against solid and liquid malignancies. Therefore, new ways to modulate this essential …

The Matteson homologation was found to be a versatile tool for the construction of the linear
polyketide side chain of meliponamycin and related compounds in only four steps. The ester …

A highly efficient asymmetric allylic alkylation of cyclic and acyclic carbon nucleophiles with
vinyl epoxides has been developed, which exhibits good functional group compatibility, high …

Covering: up to 2010 Since their first discovery in 1959, natural products containing the
piperazic acid motif have been isolated from a variety of sources and exhibit diverse …

Epoxides and aziridines are important three-membered cyclic compounds, which exhibit
high reactivity due to their strong strain in molecules. The asymmetric ring-opening reactions …

The first total synthesis of meliponamycin A, an antimicrobial cyclodepsipeptide isolated
from Streptomyces, is reported. Two key building blocks, the substituted tetrahydropyranyl …

Microtubules, consisting of α/β-tubulin heterodimers, are prime targets for anticancer drug
discovery. Gatorbulin-1 (GB1, 1a) is a recently described marine natural product that targets …