Alterations in stiffness of the trabecular meshwork (TM) may play an important role in primary
open-angle glaucoma (POAG), the second leading cause of blindness. Specifically, certain …

The ability to directly print compliant biomedical devices on live human organs could benefit
patient monitoring and wound treatment, which requires the 3D printer to adapt to the …

Adjusting the acrylamide monomer and cross-linker content in polyacrylamide gels controls
the hydrogel stiffness, yet the reported elastic modulus for the same formulations varies …

Human mesenchymal stem cells (hMSCs) are capable of probing and responding to the
mechanical properties of their substrate. Although most biological and synthetic matrices are …

Force exertion is an integral part of cellular behavior. Traction force microscopy (TFM) has
been instrumental for studying such forces, providing spatial force measurements at …

Cortical stiffness is an important cellular property that changes during migration, adhesion
and growth. Previous atomic force microscopy (AFM) indentation measurements of cells …

Contractile force generation plays a critical role in cell adhesion, migration, and extracellular
matrix reorganization in both 2D and 3D environments. Characterization of cellular forces …

Recent studies indicate that the biophysical properties of the cellular microenvironment
strongly influence a variety of fundamental cell behaviors. The extracellular matrix's (ECM) …

Podosomes are adhesion structures formed in monocyte-derived cells. They are F-actin-rich
columns perpendicular to the substrate surrounded by a ring of integrins. Here, to measure …

Gels formed by semiflexible filaments such as most biopolymers exhibit non-linear behavior
in their response to shear deformation, eg, with a pronounced strain stiffening and negative …