With the arrival of telomere-to-telomere (T2T) assemblies of the human genome comes the
computational challenge of efficiently and accurately constructing multiple genome …

Genetic tools are increasingly used to identify and discriminate between species. One key
transition in this process was the recognition of the potential of the ca 658bp fragment of the …

Understanding environmental microbiomes is central to furthering strategies for the
restoration of polluted habitats. Such studies allow us to gather important information on the …

Traditional alignment-based methods meet serious challenges in genome sequence
comparison and phylogeny reconstruction due to their high computational complexity. Here …

Current tools for estimating the substitution distance between two related sequences
struggle to remain accurate at a high divergence. Difficulties at distant homologies, such as …

Sequence alignment is at the heart of DNA and protein sequence analysis. For the data
volumes that are nowadays produced by massively parallel sequencing technologies …

Lymph-node metastasis is the most perilous cancer progressive state, where long non-
coding RNA (lncRNA) has been confirmed to be an important genetic indicator in cancer …

Background An important initial phase of arguably most homology search and alignment
methods such as required for genome alignments is seed finding. The seed finding step is …

Global sequence alignment is an essential process in bio-informatics for determining the
degree of similarity between two DNA sequences. It is performed using the Dynamic …

discovering mutations in DNA sequences is the most common approach to diagnosing many
genome-related diseases. The optimal alignment of DNA sequences is a reliable approach …