The analysis of the contributions to synaptic plasticity and memory of cAMP, PKA, CRE,
CREB-1, CREB-2, and CPEB has recruited the efforts of many laboratories all over the …

Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in
membrane remodelling, has a critical role in endocytic membrane fission events. The use of …

In the mammalian central nervous system, excitatory glutamatergic synapses harness
neurotransmission that is mediated by ion flow through α-amino-3-hydroxy-5-methyl-4 …

The synapse is the functional unit of the brain. During the last several decades we have
acquired a great deal of information on its structure, molecular components, and …

Experiences, whether they be learning in a classroom, a stressful event, or ingestion of a
psychoactive substance, impact the brain by modifying the activity and organization of …

The administration of leptin to leptin-deficient humans, and the analogous Lep ob/Lep ob
mice, effectively reduces hyperphagia and obesity,. But common obesity is associated with …

▪ Abstract Activity-dependent changes in synaptic function are believed to underlie the
formation of memories. Two prominent examples are long-term potentiation (LTP) and long …

The cellular processes that govern neuronal function are highly complex, with many basic
cell biological pathways uniquely adapted to perform the elaborate information processing …

AMPA-type glutamate receptors (AMPA-Rs) mediate a majority of excitatory synaptic
transmission in the brain. In hippocampus, most AMPA-Rs are hetero-oligomers composed …

Excitatory synapses in the CNS release glutamate, which acts primarily on two types of
ionotropic receptors: AMPA receptors and NMDA receptors. AMPA receptors mediate the …