Immunological memory is the basis of protective immunity provided by vaccines and
previous infections. Immunological memory can develop from multiple branches of the …

Tissue-resident immune cells span both myeloid and lymphoid cell lineages, have been
found in multiple human tissues, and play integral roles at all stages of the immune …

T lymphocytes migrate to barrier sites after exposure to pathogens, providing localized
immunity and long-term protection. Here, we obtained blood and tissues from human organ …

Infancy and childhood are critical life stages for generating immune memory to protect
against pathogens; however, the timing, location, and pathways for memory development in …

Older people are particularly susceptible to infectious and neoplastic diseases of the lung
and it is unclear how lifelong exposure to environmental pollutants affects respiratory …

Infants and young children are more susceptible to common respiratory pathogens than
adults but can fare better against novel pathogens like severe acute respiratory syndrome …

T cells differentiate into functionally distinct states upon antigen encounter. These states are
delineated by different cell surface markers for murine and human T cells, which hamper …

Our current knowledge of human memory CD8+ T cells is derived largely from studies of the
intravascular space. However, emerging data are starting to challenge some of the dogmas …

T cells are the central drivers of many inflammatory diseases, but the repertoire of tissue-
resident T cells at sites of pathology in human organs remains poorly understood. We …

The immune system protects us from pathogens, such as viruses. Antiviral immune
mechanisms aim to limit viral replication, and must maintain immunological homeostasis to …