Masquelet's induced membrane technique (MIMT) is a relatively new, two‐stage surgical
procedure to reconstruct segmental bone defects. First performed by Dr. Masquelet in the …

At present, bone nonunion and delayed union are still difficult problems in orthopaedics.
Since the discovery of bone morphogenetic protein (BMP), it has been widely used in …

Disclosure: The authors indicated that no external funding was received for any aspect of
this work. On the Disclosure of Potential Conflicts of Interest forms, which are provided with …

Bone reconstruction within a critical‐sized defect remains a real challenge in orthopedic
surgery. The Masquelet technique is an innovative, two‐step therapeutic approach for bone …

OBJECTIVE: Wide diaphyseal bone defects, above all those infected, encounter into
Masquelet technique a suitable treatment. The two-step procedure allows the surgeon to …

Post-traumatic long bone osteomyelitis (PTOM) is a relatively frequent occurrence in patients
with severe open fractures and requires treatment to prevent limb-threatening complications …

Objectives: To determine the optimal fixation method [intramedullary nail (IMN) vs. plate
fixation (PF)] for treating critical bone defects with the induced membrane technique, also …

Background Substantial evidence exists demonstrating the individual effectiveness of both
rhBMP-2 and-7 in the treatment of nonunions, data comparing the clinical effectiveness of …

Bone defects may impede normal biomechanics and the structural stability of bone as an
organ. In many cases, the correction of bone defects requires extensive surgical intervention …

Thanks to its biological properties, the human amniotic membrane (HAM) combined with a
bone substitute could be a single-step surgical alternative to the two-step Masquelet …