This paper is the thirty-ninth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2016 …

Chronic pain conditions are unmet medical needs, since the available drugs, opioids, non-
steroidal anti-inflammatory/analgesic drugs and adjuvant analgesics do not provide …

Endocytosis is a key regulatory mechanism adopted by G protein-coupled receptors
(GPCRs) to modulate downstream signaling responses within a stringent spatiotemporal …

Endocytosis and intracellular trafficking constitute important regulatory features associated
with G protein-coupled receptor (GPCR) function. GPCR endocytosis involves several …

One of the main health problems in many societies is the increased opium abuse, which was
found to be correlated with many problems like cardiovascular disease. This study aimed to …

Abstract Phosphatidylinositol 4, 5-bisphosphate (PI (4, 5) P2) is the most abundant
membrane phosphoinositide and cholesterol is an essential component of the plasma …

The biosynthesis of cholesterol, an essential component of higher eukaryotic membranes,
was worked out by Konrad Bloch (and Feodor Lynen) in the 1960s and they received the …

G protein-coupled receptors (GPCRs) are the largest family of transmembrane proteins that
relay extracellular signals across the plasma membrane and elicit an intricate cascade of …

It has been suggested that preculturing immature oocytes in a manner that maintains them in
meiotic arrest may improve cytoplasmic maturation and, thereby, the eventual …

Background Chronic exposure of mammalian organism to morphine results in adaption to
persistent high opioid tone through homeostatic adjustments. Our previous results indicated …