Liver cancer (LC) is the most common cause of cancer death in the United States and the
fifth most common globally. The overexpression of nuclear factor E2 related factor 2 (Nrf2) …

Hepatocellular carcinoma (HCC) is one of the leading global causes of cancer mortality.
MicroRNAs (miRNAs) are small interfering RNAs that alleviate the levels of protein …

Cell lines are valuable resources as model for human biology and translational medicine. It
is thus important to explore the concordance between the expression in various cell lines vis …

Severe acute respiratory coronavirus 2 (SARS-CoV-2) is a newly identified virus that has
resulted in over 2.5 million deaths globally and over 116 million cases globally in March …

Oncogenic RAS-induced senescence (OIS) is an autonomous tumour suppressor
mechanism associated with premalignancy,. Achieving this phenotype typically requires a …

Immunotherapy using anti-programmed death 1 ligand 1 (PD-L1) antibodies has shown
clinical efficacy against hepatocellular carcinoma (HCC) and is recognized as the first-line …

Cancer metabolism research has recently been revived and its focus expanded from
glucose and the Warburg's effects on other nutrients, such as glutamine. The underlying …

ATP citrate lyase (ACLY), a strategic metabolic enzyme that catalyzes the glycolytic to lipidic
metabolism, has gained increasing attention as an attractive therapeutic target for …

Cytostatic effects of doxorubicin in clinically applied doses are often inadequate and limited
by systemic toxicity. The main objective of this in vitro study was to determine the anti …

Mitochondria not only are the main source of ATP synthesis but also regulate cellular redox
balance and calcium homeostasis. Its dysfunction can lead to a variety of diseases and …