T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …

ATP, NAD+, and nucleic acids are abundant purines that, in addition to having critical
intracellular functions, have evolved extracellular roles as danger signals released in …

The immunosuppressive effect of adenosine in the microenvironment of a tumor is well
established. Presently, researchers are developing approaches in immune therapy that …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Increased aerobic glycolysis in endothelial cells of atheroprone areas of blood vessels has
been hypothesized to drive increased inflammation and lesion burden but direct links …

In modern societies, with an increase in the older population, age-related
neurodegenerative diseases have progressively become greater socioeconomic burdens …

Energy metabolism is key to the promotion of tumor growth, development, and metastasis. At
the same time, cellular metabolism also mediates immune cell survival, proliferation and …

Switching of vascular smooth muscle cells (VSMCs) from a contractile phenotype to a
dedifferentiated (proliferative) phenotype contributes to neointima formation, which has been …

The molecular mechanisms underlying vascular inflammation and associated inflammatory
vascular diseases are not well defined. Here we show that endothelial intracellular …

Several physiological functions of adenosine (Ado) appear to be mediated by four G protein-
coupled Ado receptors. Ado is produced extracellularly from the catabolism of the excreted …