Imidazole nucleus is a constituent of many bioactive heterocyclic compounds that are of
wide interest because of their diverse biological and clinical applications. This created …

The anticancer drug imatinib is an inhibitor of the platelet-derived growth factor receptor
(PDGFR) kinases, which are involved in the pathogenesis of fibrotic diseases. In the current …

In a search for new anticancer agents with better activity and selectivity, the present work
described the synthesis of several new series of sulfachloropyridazine hybrids with …

A series of N-(4-hydroxy-3-mercaptonaphthalen-1-yl) amides were synthesized and
investigated for their in vitro antiangiogenic activity. Among these compounds, 6d, which …

We recently identified a class of pyridyl aniline thiazoles (PAT) that displayed selective
cytotoxicity for von Hippel-Lindau (VHL) deficient renal cell carcinoma (RCC) cells in vitro …

Restenosis, the re-occlusion of a diseased vessel following a surgical intervention, is a
major cause of failure of angioplasty, stenting, and bypass grafting with natural and synthetic …

In western countries, exudative age-related macular degeneration (AMD) is one of the
leading causes of blindness in the elderly. This disease is characterized by an abnormal …

organic compounds Page 1 2-Methylsulfanyl-4-(3-pyridyl)pyrimidine Ren-Jun Du, Jian-Qiang
Wang, Sheng Bi, Yi-Xin Zhou and Cheng Guo* College of Science, Nanjing University of …

The extensive use of antimicrobial drugs resulted in drug resistance that threatens to reverse
the miracles of the last half century. To counteract the resistance produced by microbes …

For the past three decades, advances in the treatment of central nervous system (CNS)
tumors such as malignant glioma have only been modest. One particular challenge facing …