The heterogeneity of prostate cancer: a practical approach

Y Tolkach, G Kristiansen - Pathobiology, 2018 - karger.com
Prostate cancer is a paradigm tumor model for heterogeneity in almost every sense. Its
clinical, spatial, and morphological heterogeneity divided by the high-level molecular …

Gleason grading of prostate cancer in needle biopsies or radical prostatectomy specimens: contemporary approach, current clinical significance and sources of …

R Montironi, R Mazzuccheli, M Scarpelli… - BJU …, 2005 - Wiley Online Library
The Gleason grading system is a powerful tool to prognosticate and aid in the treatment of
men with prostate cancer. The needle biopsy Gleason score correlates with virtually all other …

Interobserver reproducibility of Gleason grading of prostatic carcinoma: general pathologist

WC Allsbrook Jr, KA Mangold, MH Johnson, RB Lane… - Human pathology, 2001 - Elsevier
Only a few large studies of interobserver reproducibility of Gleason grading of prostatic
carcinoma exist. Thirty-eight biopsies containing prostate cancer were distributed for …

Development and internal validation of a nomogram predicting the probability of prostate cancer Gleason sum upgrading between biopsy and radical prostatectomy …

FKH Chun, T Steuber, A Erbersdobler, E Currlin… - European urology, 2006 - Elsevier
OBJECTIVE: Previous reports indicate that as many as 43% of men with low grade PCa at
biopsy will be diagnosed with high-grade PCa at RP. We explored the rate of upgrading …

Nuclear architecture analysis of prostate cancer via convolutional neural networks

JT Kwak, SM Hewitt - IEEE access, 2017 - ieeexplore.ieee.org
In this paper, we present an approach of convolutional neural networks (CNNs) to identify
prostate cancers. Prostate tissue specimen samples were obtained from the tissue …

Multiview boosting digital pathology analysis of prostate cancer

JT Kwak, SM Hewitt - Computer methods and programs in biomedicine, 2017 - Elsevier
Abstract Background and Objective Various digital pathology tools have been developed to
aid in analyzing tissues and improving cancer pathology. The multi-resolution nature of …

Reproducibility and reliability of tumor grading in urological neoplasms

R Engers - World journal of urology, 2007 - Springer
Histopathologic tumor grading reflects the degree of differentiation of a given tumor and for
most urological tumors grading is an important factor in predicting their biological …

Intraobserver and interobserver reproducibility of WHO and Gleason histologic grading systems in prostatic adenocarcinomas

ŞO Özdamar, Ş Sarikaya, L Yildiz, MK Atilla… - … urology and nephrology, 1996 - Springer
In this study a total of 96 patients with prostatic carcinoma were evaluated retrospectively.
Sections prepared from paraffin blocks were examined and all cases were scored according …

Gleason scores of prostate biopsy and radical prostatectomy specimens over the past 10 years: is there evidence for systematic upgrading?

EB Smith, HF Frierson Jr, SE Mills, JC Boyd… - Cancer, 2002 - Wiley Online Library
BACKGROUND With the advent of the prostate specific antigen (PSA) assay, an increased
detection rate of prostate carcinoma has ensued. This has been associated with a …

Accuracy of Gleason grading by practicing pathologists and the impact of education on improving agreement

Y Mikami, T Manabe, JI Epstein, T Shiraishi… - Human pathology, 2003 - Elsevier
The aims of this study were to evaluate the accuracy of Gleason grading for prostatic
adenocarcinoma among practicing pathologists in Japan and to determine the influence of …