A review of modifications of quinoline antimalarials: mefloquine and (hydroxy) chloroquine

DJ Kucharski, MK Jaszczak, PJ Boratyński - Molecules, 2022 - mdpi.com
Late-stage modification of drug molecules is a fast method to introduce diversity into the
already biologically active scaffold. A notable number of analogs of mefloquine, chloroquine …

Exploring the potential of metallodrugs as chemotherapeutics for triple negative breast cancer

N Nayeem, M Contel - Chemistry–A European Journal, 2021 - Wiley Online Library
This review focuses on studies of coordination and organometallic compounds as potential
chemotherapeutics against triple negative breast cancer (TNBC) which has one of the …

Copper (I)–phosphine polypyridyl complexes: synthesis, characterization, DNA/HSA binding study, and antiproliferative activity

W Villarreal, L Colina-Vegas, G Visbal… - Inorganic …, 2017 - ACS Publications
A series of copper (I)–phosphine polypyridyl complexes have been investigated as potential
antitumor agents. The complexes [Cu (PPh3) 2dpq] NO3 (2),[Cu (PPh3) 2dppz] NO3 (3),[Cu …

Transition metal intercalators as anticancer agents—recent advances

KM Deo, BJ Pages, DL Ang, CP Gordon… - International journal of …, 2016 - mdpi.com
The diverse anticancer utility of cisplatin has stimulated significant interest in the
development of additional platinum-based therapies, resulting in several analogues …

RuII(p-cymene) Compounds as Effective and Selective Anticancer Candidates with No Toxicity in Vivo

OA Lenis-Rojas, MP Robalo, AI Tomaz… - Inorganic …, 2018 - ACS Publications
Ruthenium (II) complexes are currently considered a viable alternative to the widely used
platinum complexes as efficient anticancer agents. We herein present the synthesis and …

Half sandwich Ru (II)-acylthiourea complexes: DNA/HSA-binding, anti-migration and cell death in a human breast tumor cell line

L Colina-Vegas, L Luna-Dulcey, AM Plutín… - Dalton …, 2017 - pubs.rsc.org
Organometallic ruthenium complexes as potential anticancer agents have been explored
due to their suitable properties, such as stability in the solid state and in solution, water …

Antimalarial Agents Derived from Metal‐Amodiaquine Complexes with Activity in Multiple Stages of the Plasmodium Life Cycle

L Colina‐Vegas, M da Cruz B. Silva… - … A European Journal, 2023 - Wiley Online Library
Malaria is the one of the deadliest infectious diseases worldwide. Chemically, quinolines are
excellent ligands for metal coordination and are deployed as drugs for malaria treatment …

Transport of the Ruthenium Complex [Ru(GA)(dppe)2]PF6 into Triple-Negative Breast Cancer Cells Is Facilitated by Transferrin Receptors

MA Naves, AE Graminha, LC Vegas… - Molecular …, 2019 - ACS Publications
The triple-negative breast cancer subtype (TNBC) is highly aggressive and metastatic and
corresponds to 15–20% of diagnosed cases. TNBC treatment is hampered, because these …

Selective Ru (II)/lawsone complexes inhibiting tumor cell growth by apoptosis

KM Oliveira, LD Liany, RS Corrêa, VM Deflon… - Journal of inorganic …, 2017 - Elsevier
New Ru (II) complexes with lawsone (law) characterized as trans-[Ru (law)(PPh 3) 2 (NN)]
PF 6, where PPh 3 means triphenylphosphine and NN is 2, 2′-bipyridine (1), 4, 4 …

Half-sandwich organometallic Ru and Rh complexes of (N, N) donor compounds: Effect of ligand methylation on solution speciation and anticancer activity

JP Mészáros, VFS Pape, G Szakács, G Németi… - Dalton …, 2021 - pubs.rsc.org
A series of half-sandwich polypyridyl complexes was synthesized and compared focusing
on structural, cytotoxic and aqueous solution behaviour. The formula of the synthesized …