Purpose Xylazine is an alpha-2-adrenergic agonist used for its sedative and analgesic
properties in veterinary medicine. While not approved by the Food and Drug Administration …

Xylazine is not a controlled substance; it is marketed as a veterinary drug and used as a
sedative, analgesic and muscle relaxant. In humans, it could cause central nervous system …

Introduction and objectives: The opioid overdose epidemic is exacerbated by the
emergence of Xylazine as an illicit drug adulterant. Xylazine, a veterinary sedative, can …

The current opioid overdose crisis is characterized by the presence of unknown
psychoactive adulterants. Xylazine is an alpha-2 receptor agonist that is not approved for …

Xylazine is an alpha-adrenergic receptor agonist approved for use only in animals with a
prescription from a veterinarian. It is a powerful sedative that is slowly infiltrating the …

Human xylazine use in Puerto Rico merits particular attention for its unprecedented scale
and depth. Although Puerto Rican injecting drug users (IDUs) have reported using this drug …

In the 1960s, Bayer 1470, an alpha2-adrenergic agonist similar to clonidine, was
investigated as an antihypertensive in humans, only to be abandoned because it produced …

In order to assess the extent of xylazine (Xyz) injection in Puerto Rico, two waves of used-
syringe collections were performed. In the first, syringes were gathered, anonymously and …

Presently, investigations of drug‐facilitated crimes (DFCs) rely on the detection of
substances extracted from biological samples following intake by the victim. However, such …

Xylazine, a veterinary sedative, has been found as an adulterant of heroin in street drugs in
Puerto Rico. It was found in combination with free morphine and 6-acetylmorphine, codeine …