A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …

After fertilization, the quiescent zygote experiences a burst of genome activation that initiates
a short-lived totipotent state. Understanding the process of totipotency in human cells would …

Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …

Postnatal growth of mammalian oocytes is accompanied by a progressive gain of DNA
methylation, which is predominantly mediated by DNMT3A, a de novo DNA …

In many organisms, the methylation of cytosine in DNA has a key role in silencing'parasitic'
DNA elements, regulating transcription and establishing cellular identity. The recent …

DNA methylation is a heritable epigenetic modification involved in gene silencing,
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …

DNA methylation is a chemical modification that defines cell type and lineage through the
control of gene expression and genome stability. Disruption of DNA methylation control …

DNA methylation is one of the best-characterized epigenetic modifications and has been
implicated in numerous biological processes, including transposable element silencing …

In mammalian development, epigenetic modifications, including DNA methylation patterns,
play a crucial role in defining cell fate but also represent epigenetic barriers that restrict …