Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity between depression and neurodegenerative disorders

H Anisman, Z Merali, S Hayley - Progress in neurobiology, 2008 - Elsevier
Given the array of biological changes induced by stressors, it is not surprising that these
experiences may provoke a variety of illnesses. Among others things, stressors promote …

Functions and regulatory mechanisms of Gq-signaling pathways

N Mizuno, H Itoh - Neurosignals, 2009 - karger.com
Gq family members of heterotrimeric G protein activate β isoforms of phospholipase C that
hydrolyzes phosphatidylinositol phosphate to diacylglycerol and inositol trisphosphate …

Calcium and activity-dependent signaling in the developing cerebral cortex

A Arjun McKinney, R Petrova… - Development, 2022 - journals.biologists.com
Calcium influx can be stimulated by various intra-and extracellular signals to set coordinated
gene expression programs into motion. As such, the precise regulation of intracellular …

Diet‐induced obesity in female mice leads to peroxidized lipid accumulations and impairment of hippocampal neurogenesis during the early life of their offspring

Y Tozuka, E Wada, K Wada - The FASEB Journal, 2009 - Wiley Online Library
Maternal obesity may affect the child's long‐term development and health. However, there is
little information about the involvement of maternal obesity in the brain development of …

Alternative splicing of the pituitary adenylate cyclase-activating polypeptide receptor PAC1: mechanisms of fine tuning of brain activity

J Blechman, G Levkowitz - Frontiers in endocrinology, 2013 - frontiersin.org
Alternative splicing of the precursor mRNA encoding for the neuropeptide receptor
PAC1/ADCYAP1R1 generates multiple protein products that exhibit pleiotropic activities …

Pituitary adenylate cyclase-activating polypeptide: 30 years in research spotlight and 600 million years in service

V Denes, P Geck, A Mester, R Gabriel - Journal of Clinical Medicine, 2019 - mdpi.com
Emerging from the depths of evolution, pituitary adenylate cyclase-activating polypeptide
(PACAP) and its receptors (ie, PAC1, VPAC1, VPAC2) are present in multicellular organisms …

The neural stem cell secretome across neurodevelopment

TJ Dause, JK Denninger, BM Smith, ED Kirby - Experimental Neurology, 2022 - Elsevier
Neural stem cell (NSC) based therapies are at the forefront of regenerative medicine
strategies to combat illness and injury of the central nervous system (CNS). In addition to …

Calcium signaling in neocortical development

P Uhlen, N Fritz, E Smedler… - Developmental …, 2015 - Wiley Online Library
ABSTRACT The calcium ion (Ca2+) is an essential second messenger that plays a pivotal
role in neurogenesis. In the ventricular zone (VZ) of the neocortex, neural stem cells linger to …

G-protein-coupled receptors in adult neurogenesis

VA Doze, DM Perez, DR Sibley - Pharmacological reviews, 2012 - Elsevier
The importance of adult neurogenesis has only recently been accepted, resulting in a
completely new field of investigation within stem cell biology. The regulation and functional …

Cellular prion protein promotes post-ischemic neuronal survival, angioneurogenesis and enhances neural progenitor cell homing via proteasome inhibition

TR Doeppner, B Kaltwasser, J Schlechter… - Cell death & …, 2015 - nature.com
Although cellular prion protein (PrP c) has been suggested to have physiological roles in
neurogenesis and angiogenesis, the pathophysiological relevance of both processes …