Microvascular endothelial cells in the kidney have been a neglected cell type in sepsis-
induced acute kidney injury (sepsis-AKI) research; yet, they offer tremendous potential as …

Sepsis is one of the leading causes of deaths world-wide and yet there are no therapies
available other than ICU treatment. The patient outcome is determined by a complex …

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) exert anti-inflammatory effects
relevant to the chronic complications of type 2 diabetes. Although GLP-1RAs attenuate T cell …

Sepsis is an often deadly complication of infection in which systemic inflammation damages
the vasculature, leading to tissue hypoperfusion and multiple organ failure. Currently, the …

The discovery of TMEM173/STING-dependent innate immunity has recently provided
guidance for the prevention and management of inflammatory disorders. Here, we show that …

Pyroptosis is a programmed necrotic cell death executed by gasdermins, a family of pore-
forming proteins. The cleavage of gasdermins by specific proteases enables their pore …

Macrophage scavenger receptor 1 (MSR1), also named CD204, holds key inflammatory
roles in multiple pathophysiologic processes. Present primarily on the surface of various …

Acute respiratory distress syndrome (ARDS) is a common disease entity in critical care
medicine and is still associated with a high mortality. Because of the heterogeneous …

Sepsis is a challenging clinical syndrome caused by a dysregulated host response to
infection. Here, we identified an unexpected proseptic activity of aconitate decarboxylase 1 …

Sepsis is a systemic response to infection with life-threatening consequences. Our
understanding of the molecular and cellular impact of sepsis across organs remains …