Part I of this article discussed the potential functional importance of genetic mutations and
alleles of the human cytochrome P450 2D6 (CYP2D6) gene. The impact of CYP2D6 …

Clinicians understand that individual patients differ in their response to specific opioid
analgesics and that patients may require trials of several opioids before finding an agent that …

▪ Abstract Summary of consensus: 1. The use of opioids in cancer pain: The criteria for
selecting analgesics for pain treatment in the elderly include, but are not limited to, overall …

We investigated the elimination routes for the 200 drugs that are sold most often by
prescription count in the United States. The majority (78%) of the hepatically cleared drugs …

The experience of pain in cancer is widely accepted as a major threat to quality of life, and
the relief of pain has emerged as a priority in oncology care. Pain is associated with both the …

Written for practitioners in the field, this critically acclaimed bestseller provides authoritative
information focused on the investigation of drug-related deaths and practical approaches to …

Opioids are used for acute and chronic pain and dependency. They have a narrow
therapeutic index and large interpatient variability in response. Genetic factors regulating …

The emergence of clinically efficacious prescription drugs to treat pain, anxiety, and learning
disorders is accompanied by the potential for nonmedical use. Prescription drug abuse has …

Pain Physician: March/April 2011; 14: 123-143 124 www. painphysicianjournal. com
patterns of drug use and compliance so as to direct the type and conduct of treatment that …

Background: Eight analgesic preparations with approved indications for acute pain were
among the top 200 drugs prescribed in the United States in 2006. In addition, an estimated …