Revisiting Trigonella foenum-graecum L.: Pharmacology and Therapeutic Potentialities

T Visuvanathan, LTL Than, J Stanslas, SY Chew… - Plants, 2022 - mdpi.com
Fenugreek (Trigonella foenum-graecum L.) is a medicinal plant that has been used as a
food condiment as well as for its multiple therapeutic characteristics since ancient times …

The ongoing pursuit of neuroprotective therapies in Parkinson disease

D Athauda, T Foltynie - Nature Reviews Neurology, 2015 - nature.com
Many agents developed for neuroprotective treatment of Parkinson disease (PD) have
shown great promise in the laboratory, but none have translated to positive results in …

Nutritional and therapeutic properties of fenugreek (Trigonella foenum-graecum): a review

QA Syed, Z Rashid, MH Ahmad, R Shukat… - … Journal of Food …, 2020 - Taylor & Francis
Current lifestyle, eating habits, stress, environmental factors and intensive use of synthetic
chemicals in food processing and agriculture have radically increased the progression of …

A review on therapeutic potentials of Trigonella foenum graecum (fenugreek) and its chemical constituents in neurological disorders: Complementary roles to its …

S Zameer, AK Najmi, D Vohora… - Nutritional Neuroscience, 2018 - Taylor & Francis
Objectives: The growing rate of neurological disorders is a major concern in today's
scenario. Today's research is focusing on therapeutic interventions providing benefits in …

Protective Effects of Salidroside in the MPTP/MPP+-Induced Model of Parkinson's Disease through ROS–NO-Related Mitochondrion Pathway

S Wang, H He, L Chen, W Zhang, X Zhang… - Molecular neurobiology, 2015 - Springer
Parkinson's disease is a progressive neurodegenerative disease causing tremor, rigidity,
bradykinesia, and gait impairment. Oxidative stress and mitochondrial dysfunction play …

Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease

KR Brunden, JQ Trojanowski, AB Smith III… - Bioorganic & medicinal …, 2014 - Elsevier
Microtubules (MTs), cytoskeletal elements found in all mammalian cells, play a significant
role in cell structure and in cell division. They are especially critical in the proper functioning …

Neuroprotective actions of glucagon-like peptide-1 (GLP-1) analogues in Alzheimer's and Parkinson's diseases

AF Batista, V Bodart-Santos, FG De Felice, ST Ferreira - CNS drugs, 2019 - Springer
The current absence of effective treatments for Alzheimer's disease (AD) and Parkinson's
disease (PD) reflects an incomplete knowledge of the underlying disease processes …

Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress

JG Farias, EA Herrera, C Carrasco-Pozo… - Pharmacology & …, 2016 - Elsevier
Hypoxia is the failure of oxygenation at the tissue level, where the reduced oxygen delivered
is not enough to satisfy tissue demands. Metabolic depression is the physiological …

Upregulation of alphaB-crystallin expression in the substantia nigra of patients with Parkinson's disease

Y Liu, Q Zhou, M Tang, N Fu, W Shao, S Zhang… - Neurobiology of …, 2015 - Elsevier
Parkinson's disease (PD) is one of the most devastating neurodegenerative disorders. The
underlying mechanisms of the characteristic neurodegeneration in the substantia nigra (SN) …

Development and optimization of halogenated vinyl sulfones as Nrf2 activators for the treatment of Parkinson's disease

JW Choi, S Kim, JS Yoo, HJ Kim, HJ Kim… - European Journal of …, 2021 - Elsevier
The Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2
(Nrf2) signaling pathway plays a pivotal role in the cellular defense system against oxidative …