Cancer spheroids and organoids as novel tools for research and therapy: state of the art and challenges to guide precision medicine
S El Harane, B Zidi, N El Harane, KH Krause, T Matthes… - Cells, 2023 - mdpi.com
Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …
Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture
A cell spheroid is a three-dimensional (3D) aggregation of cells. Synthetic, in-vitro spheroids
provide similar metabolism, proliferation, and species concentration gradients to those found …
provide similar metabolism, proliferation, and species concentration gradients to those found …
Spheroid engineering in microfluidic devices
Two-dimensional (2D) cell culture techniques are commonly employed to investigate
biophysical and biochemical cellular responses. However, these culture methods, having …
biophysical and biochemical cellular responses. However, these culture methods, having …
High blood flow shear stress values are associated with circulating tumor cells cluster disaggregation in a multi-channel microfluidic device
Metastasis represents a dynamic succession of events involving tumor cells which
disseminate through the organism via the bloodstream. Circulating tumor cells (CTCs) can …
disseminate through the organism via the bloodstream. Circulating tumor cells (CTCs) can …
Mimicking human pathophysiology in organ‐on‐chip devices
Convergence of life sciences, engineering, and basic sciences has opened new horizons for
biologically inspired innovations, and a considerable number of organ‐on‐a‐chip platforms …
biologically inspired innovations, and a considerable number of organ‐on‐a‐chip platforms …
Comparative cytotoxicity of seven per-and polyfluoroalkyl substances (PFAS) in six human cell lines
Human exposures to perfluoroalkyl and polyfluoroalkyl substances (PFAS) have been linked
to several diseases associated with adverse health outcomes. Animal studies have been …
to several diseases associated with adverse health outcomes. Animal studies have been …
Fabrication of PNIPAm-based thermoresponsive hydrogel microwell arrays for tumor spheroid formation
Abstract Complex three-dimensional (3D) cell cultures are being increasingly implemented
in biomedical research as they provide important insights into complex cancer biology, and …
in biomedical research as they provide important insights into complex cancer biology, and …
[HTML][HTML] Nanobiotechnological approaches for breast cancer Management: Drug delivery systems and 3D In-Vitro models
The science of nanotechnology has been proposed as a factor of main change in the field of
cancer diagnosis and treatment. The challenges in common clinical treatment of breast …
cancer diagnosis and treatment. The challenges in common clinical treatment of breast …
Applications of microfluidics in quantitative biology
Quantitative biology is dedicated to taking advantage of quantitative reasoning and
advanced engineering technologies to make biology more predictable. Microfluidics, as an …
advanced engineering technologies to make biology more predictable. Microfluidics, as an …
Analysis of cellular response to drugs with a microfluidic single-cell platform based on hyperspectral imaging
L Liu, L Zhang, X Zhang, X Dong, X Jiang, X Huang… - Analytica Chimica …, 2024 - Elsevier
Background Cellular response to pharmacological action of drugs is significant for drug
development. Traditional detection method for cellular response to drugs normally rely on …
development. Traditional detection method for cellular response to drugs normally rely on …