The integration of gene therapy into tissue engineering to control differentiation and direct
tissue formation is not a new concept; however, successful delivery of nucleic acids into …

Cells integrate physicochemical signals on the nanoscale from the local microenvironment,
resulting in altered functional nuclear landscape and gene expression. These alterations …

Osteoarthritis is a chronic disease that can be initiated by altered joint loading or injury of the
cartilage. The mechanically sensitive PIEZO ion channels have been shown to transduce …

For cells to adapt to different tissues and changes in tissue mechanics, they must be able to
respond to mechanical cues by changing their gene expression patterns. Biochemical …

Objective Chondrocytes, the sole cell type in articular cartilage, maintain the extracellular
matrix (ECM) through a homeostatic balance of anabolic and catabolic activities that are …

Mechanically sensitive tissues (eg, skeletal muscles) greatly need mechanical stimuli during
the development and maturation. The extracellular matrix (ECM) mediates these signals …

The multi-directional mechanical stimulation experienced by articular cartilage during
motion is transferred to the chondrocytes through a thin layer of pericellular matrix around …

To withstand physiological loading over a lifetime, human synovial joints are covered and
protected by articular cartilage, a layer of low-friction, load-bearing tissue. The unique …

The aim of osteochondral tissue engineering is to achieve the complex, functional and three-
dimensional tissue regeneration under well defined, controlled and reproducible conditions …

The cytoskeleton is known to play an important role in the biomechanical nature and
structure of cells, but its particular function in compressive characteristics has not yet been …