Metabolic diseases, including obesity, diabetes mellitus and cardiovascular disease, are a
major threat to health in the modern world, but efforts to understand the underlying …

In mammals, white adipose tissues are largely divided into visceral epididymal adipose
tissue (EAT) and subcutaneous inguinal adipose tissue (IAT) with distinct metabolic …

Bone marrow adipocytes (BMA) exert pleiotropic roles beyond mere lipid storage and filling
of bone marrow (BM) empty spaces, and we are only now beginning to understand their …

Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that is a vital
regulator of adipogenesis, insulin sensitivity, and lipid metabolism. Activation of PPARγ by …

Most of the single-nucleotide polymorphisms (SNPs) associated with insulin resistance (IR)-
relevant phenotypes by genome-wide association studies (GWASs) are located in …

Current preclinical studies in drug development utilize high-throughput in vitro screens to
identify drug leads, followed by both in vitro and in vivo models to predict lead candidates' …

The origins of pharmacogenetics date back to the 1950s, when it was established that inter-
individual differences in drug response are partially determined by genetic factors. Since …

Energy-storing white adipocytes maintain their identity by suppressing the energy-burning
thermogenic gene program of brown and beige adipocytes. Here, we reveal that the protein …

Adipose-derived stem cells (ADSCs) have promising applications in tissue regeneration.
Currently, there are only a few ADSC products that have been approved for clinical use. The …

Background As a result of a sedentary lifestyle and excess food consumption in modern
society, non-alcoholic fatty liver disease (NAFLD) characterized by fat accumulation in the …