Mitochondrial uncoupling can be defined as a dissociation between mitochondrial
membrane potential generation and its use for mitochondria-dependent ATP synthesis …

Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …

Cellular function requires coordination between different organelles and metabolic cues.
Mitochondria and lysosomes are essential for cellular metabolism as major contributors of …

Autoantibodies against nucleic acids and excessive type I interferon (IFN) are hallmarks of
human systemic lupus erythematosus (SLE). We previously reported that SLE neutrophils …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

The pathogenesis of chronic obstructive pulmonary disease (COPD) remains unclear, but
involves loss of alveolar surface area (emphysema) and airway inflammation (bronchitis) as …

Small molecules are pharmacological tools of considerable value for dissecting complex
biological processes and identifying potential therapeutic interventions. Recently, the …

Mitochondria play an important role in maintaining cardiac homeostasis by supplying the
major energy required for cardiac excitation–contraction coupling as well as controlling the …

Defective mitophagy linked to dysfunction in the proteins Parkin and PTEN-induced putative
kinase 1 (PINK1) is implicated in the pathogenesis of Parkinson's disease. Although the …

The precise degradation of dysfunctional mitochondria by mitophagy is essential for
maintaining neuronal homeostasis. HTT (huntingtin) can interact with numerous other …