Multivalent proteins and nucleic acids, collectively referred to as multivalent associative
biomacromolecules, provide the driving forces for the formation and compositional …

Biomolecular condensates constitute a newly recognized form of spatial organization in
living cells. Although many condensates are believed to form as a result of phase …

Highly disordered complexes between oppositely charged intrinsically disordered proteins
present a new paradigm of biomolecular interactions. Here, we investigate the driving forces …

Coacervation has emerged as a prevalent mechanism to compartmentalize biomolecules in
living cells. Synthetic coacervates help in understanding the assembly process and mimic …

Biomolecular condensates are viscoelastic materials. Here we investigate the determinants
of the sequence-encoded and age-dependent viscoelasticity of condensates formed by the …

Biomolecular condensates, formed through phase separation, are upending our
understanding in much of molecular, cell, and developmental biology. There is an urgent …

Phase-separated biomolecular condensates exhibit a wide range of dynamic properties,
which depend on the sequences of the constituent proteins and RNAs. However, it is …

Biomolecular condensates form via processes that combine phase separation and
reversible associations of multivalent macromolecules. Condensates can be two-or …

Phase separation and percolation contribute to phase transitions of multivalent
macromolecules. Contributions of percolation are evident through the viscoelasticity of …

Membraneless coacervate microdroplets have long been proposed as model protocells as
they can grow, divide, and concentrate RNA by natural partitioning. However, the rapid …