Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is
classified as familial and sporadic. The dominant familial or autosomal presentation …

For years, it has been held that cathepsin D (CD) is involved in rather non-specific protein
degradation in a strongly acidic milieu of lysosomes. Studies with CD knock-out mice …

Alpha‐macroglobulins are ancient proteins that include monomeric, dimeric, and tetrameric
family members. In humans, and many other mammals, the predominant alpha …

In familial neurodegenerative disorders, protein aggregates form continuously because of
genetic mutations that drive the synthesis of truncated or unfolded proteins. The oxidative …

Lysosomes are acidic, membrane-bound organelles that serve as the primary catabolic
compartment of the cell. They are crucial to a variety of cellular processes from nutrient …

Protein misfolding underlies the pathology of a large number of human disorders, many of
which are age-related. An exception to this is preeclampsia, a leading cause of pregnancy …

The traditional approach in case-control association studies, to evaluate candidate genes
individually, either single markers or haplotypes, has had limited success. The multifactorial …

Cathepsin D (CTSD) is a lysosomal protease important for the degradation of various
substrates, including disease-associated proteins like α-synuclein (a-syn), amyloid …

While the clinical and neuropathological characterization of Alzheimer's Disease (AD) is well
defined, our understanding of the progression of pathologic mechanisms in AD remains …

Aim. The incidence of Alzheimer's disease (AD) has been increasing in recent years, but
there exists no cure and the pathological mechanisms are not fully understood. This study …