In neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD)
and prion diseases, deposits of aggregated disease-specific proteins are found. Oligomeric …

OBJECT Chloroquine (CQ) is a quinoline-based drug widely used for the prevention and
treatment of malaria. More recent studies have provided evidence that this drug may also …

Background The propagation of prions, the causative agents of Creutzfeldt-Jakob disease
and other human prion diseases, requires post-translational conversion of normal cellular …

Objective: To determine whether oral quinacrine increases survival in sporadic Creutzfeldt-
Jakob disease (sCJD). Methods: This NIH/National Institute on Aging–funded, double …

Quinacrine is a potent antiprion compound in cell culture models of prion disease but has
failed to show efficacy in animal bioassays and human clinical trials. Previous studies …

Many animal models in different species have been developed for mental and behavioral
disorders. This review presents large animals (dog, ovine, swine, horse) as potential models …

Neuroinflammation plays a crucial role in the development of neurodegenerative protein
misfolding disorders. This category of progressive diseases includes, but is not limited to …

Only a few years ago, pharmacotherapy of Creutzfeldt-Jakob disease was inconceivable.
The enigmatic prion agent causing Creutzfeldt-Jakob disease, consisting solely of a …

Quinacrine's ability to reduce levels of pathogenic prion protein (PrPSc) in mouse cells
infected with experimentally adapted prions led to several unsuccessful clinical studies in …

Transmissible spongiform encephalopathies (TSE) arise as a consequence of infection of
the central nervous system by prions and are incurable. To date, most antiprion compounds …