Chronic intermittent hypoxia facilitates the development of angiotensin II-induced abdominal aortic aneurysm in male mice

N Sharma, A Khalyfa, D Cai… - Journal of Applied …, 2024 - journals.physiology.org
Obstructive sleep apnea (OSA), characterized by episodes of intermittent hypoxia (IH), is
highly prevalent in patients with abdominal aortic aneurysm (AAA). However, whether IH …

Endothelial sodium channel activation mediates DOCA-salt-induced endothelial cell and arterial stiffening

L Zhang, Y Yang, AR Aroor, G Jia, Z Sun, A Parrish… - Metabolism, 2022 - Elsevier
Introduction High salt intake and aldosterone are both associated with vascular stiffening in
humans. However, our preliminary work showed that high dietary salt alone did not increase …

Interleukin 12p40 deficiency promotes abdominal aortic aneurysm by activating CCN2/MMP2 pathways

N Sharma, CP Hans - Journal of the American Heart Association, 2021 - Am Heart Assoc
Background Development of abdominal aortic aneurysm (AAA) is associated with
proinflammatory cytokines including interleukin‐12 (IL12). Deficiency of interleukin 12p40 …

AT2R agonist NP‐6A4 mitigates aortic stiffness and proteolytic activity in mouse model of aneurysm

N Sharma, AM Belenchia… - Journal of Cellular …, 2020 - Wiley Online Library
Clinical and experimental studies show that angiotensin II (AngII) promotes vascular
pathology via activation of AngII type 1 receptors (AT1Rs). We recently reported that NP …

Endothelial cell serum and glucocorticoid regulated kinase 1 (SGK1) mediates vascular stiffening

L Zhang, Z Sun, Y Yang, A Mack, M Rodgers, A Aroor… - Metabolism, 2024 - Elsevier
Background Excessive dietary salt intake increases vascular stiffness in humans, especially
in salt-sensitive populations. While we recently suggested that the endothelial sodium …

Assessment of the global and regional circumferential strain of abdominal aortic aneurysm with different size by speckle‐tracking echocardiography

T Li, X Liu, H Sun, H Ning, J Yang… - Journal of Ultrasound in …, 2021 - Wiley Online Library
Objectives We aimed to use speckle‐tracking echocardiography (STE) to quantify
circumferential aortic strain of abdominal aortic aneurysms (AAA) with different size …

[HTML][HTML] Short-Term Proteasome Inhibition: Assessment of the Effects of Carfilzomib and Bortezomib on Cardiac Function, Arterial Stiffness, and Vascular Reactivity

CD Wesley, A Sansonetti, CHG Neutel, DN Krüger… - Biology, 2024 - mdpi.com
Proteasome inhibitors such as bortezomib and carfilzomib induce apoptosis and are a
cornerstone in the treatment of relapsed or refractory multiple myeloma. However, concerns …

Abdominal aortic endothelial dysfunction occurs in female mice with dextran sodium sulfate-induced chronic colitis independently of reactive oxygen species formation

H Wu, T Hu, L Zhang, X Xia, X Liu, Q Zhu… - Frontiers in …, 2022 - frontiersin.org
Background and Objective Inflammatory bowel disease (IBD) produces significant local and
systemic inflammation with increased reactive oxygen species (ROS) formation. IBD Patients …

Vascular ultrasound for in vivo assessment of arterial pathologies in a murine model of atherosclerosis and aortic aneurysm

A Hof, H Guthoff, M Ahdab, M Landerer… - International Journal of …, 2023 - mdpi.com
Vascular diseases like atherosclerosis and abdominal aortic aneurysm (AAA) are common
pathologies in the western world, promoting various potentially fatal conditions. Here, we …

frontiers Frontiers in Cardiovascular Medicine ORIGINAL RESEARCH published: 07 April 2022

H Chen, K Gupta, C Oury, H Wu, T Hu¹t… - Insights in …, 2024 - books.google.com
Methods and Results: Acute and chronic colitis models were induced in male and female
C57BL/6 mice with dextran sodium sulfate (DSS) treatment. Aortic wall stiffness, endothelial …