Protein lactylation induced by neural excitation
Lactate has diverse roles in the brain at the molecular and behavioral levels under
physiological and pathophysiological conditions. This study investigates whether lysine …
physiological and pathophysiological conditions. This study investigates whether lysine …
Redistribution of ASIC1a channels triggered by IL-6: Potential role of ASIC1a in neuroinflammation
LCS Castellanos, RG Gatto, GOM Malnati… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Abstract Cytokines, particularly IL-6, play a crucial role in modulating immune responses in
the central nervous system (CNS). Elevated IL-6 levels have been observed in …
the central nervous system (CNS). Elevated IL-6 levels have been observed in …
Acute and chronic effects of oral administration of a medium‐chain fatty acid, capric acid, on locomotor activity and anxiety‐like and depression‐related behaviors in …
H Shoji, H Kunugi, T Miyakawa - Neuropsychopharmacology …, 2022 - Wiley Online Library
Aim Capric acid (also known as decanoic acid or C10) is one of the fatty acids in the medium‐
chain triglycerides (MCTs) commonly found in dietary fats. Although dietary treatment with …
chain triglycerides (MCTs) commonly found in dietary fats. Although dietary treatment with …
Altered brain energy metabolism related to astrocytes in Alzheimer's disease
K Hirata, K Matsuoka, K Tagai, H Endo… - Annals of …, 2024 - Wiley Online Library
Objective Increasing evidence suggests that reactive astrocytes are associated with
Alzheimer's disease (AD). However, its underlying pathogenesis remains unknown. Given …
Alzheimer's disease (AD). However, its underlying pathogenesis remains unknown. Given …
The gene expression patterns as surrogate indices of pH in the brain
Hydrogen ion (H+) is one of the most potent intrinsic neuromodulators in the brain in terms of
concentration. Changes in H+ concentration, expressed as pH, are thought to be associated …
concentration. Changes in H+ concentration, expressed as pH, are thought to be associated …
Brain energy metabolism in two states of mind measured by phosphorous magnetic resonance spectroscopy
M Galijašević, R Steiger, M Regodić… - Frontiers in Human …, 2021 - frontiersin.org
Introduction: Various functional neuroimaging studies help to better understand the changes
in brain activity during meditation. The purpose of this study was to investigate how brain …
in brain activity during meditation. The purpose of this study was to investigate how brain …
Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive …
Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential
surrogate marker for metabolic changes during neuronal excitation. These changes in …
surrogate marker for metabolic changes during neuronal excitation. These changes in …