Exploration of CviR-mediated quorum sensing inhibitors from Cladosporium spp. against Chromobacterium violaceum through computational studies
M Murali, F Ahmed, HG Gowtham, JO Aribisala… - Scientific Reports, 2023 - nature.com
An opportunistic human pathogenic bacterium, Chromobacterium violaceum resists the
potency of most antibiotics by exploiting the quorum sensing system within their community …
potency of most antibiotics by exploiting the quorum sensing system within their community …
Sphagneticola trilobata (L.) Pruski: An updated exploration of its traditional applications, taxonomy, phytochemical profile and pharmacological properties
MT Ali, DA Al-Mahdy, AM El Fishawy… - South African Journal of …, 2024 - Elsevier
Sphagneticola trilobata, one of the ornamental creeping plants, belongs to family
Asteraceae. This species has undergone several classification changes including …
Asteraceae. This species has undergone several classification changes including …
Friedelin: Structure, Biosynthesis, Extraction, and Its Potential Health Impact
SK Singh, S Shrivastava, AK Mishra, D Kumar… - Molecules, 2023 - mdpi.com
Pharmaceutical companies are investigating more source matrices for natural bioactive
chemicals. Friedelin (friedelan-3-one) is a pentacyclic triterpene isolated from various plant …
chemicals. Friedelin (friedelan-3-one) is a pentacyclic triterpene isolated from various plant …
The combination of multi-approach studies to explore the potential therapeutic mechanisms of imidazole derivatives as an MCF-7 inhibitor in therapeutic strategies
Breast cancer covers a large area of research because of its prevalence and high frequency
all over the world. This study is based on drug discovery against breast cancer from a series …
all over the world. This study is based on drug discovery against breast cancer from a series …
Secondary metabolites of Trichoderma spp. as EGFR tyrosine kinase inhibitors: Evaluation of anticancer efficacy through computational approach
HG Gowtham, PD Revanasiddappa, M Murali… - Plos one, 2024 - journals.plos.org
The present study explores the epidermal growth factor receptor (EGFR) tyrosine kinase
inhibition efficacy of secondary metabolites in Trichoderma spp. through molecular docking …
inhibition efficacy of secondary metabolites in Trichoderma spp. through molecular docking …
Unlocking the potential of approved drugs for the allosteric inhibition of tropomyosin-receptor kinase A using molecular docking and molecular dynamics studies
RM Mukhtar, N Abdelmoniem, HA Elrufaie… - Frontiers in …, 2023 - frontiersin.org
Tropomyosin-receptor kinase A (TrkA) is the primary isoform among the tropomyosin-
receptor kinases that have been associated with human cancer development, contributing to …
receptor kinases that have been associated with human cancer development, contributing to …
Integrated network pharmacology and molecular docking to investigate the potential mechanism of Tufuling on Alzheimer's disease
Z Zhang, J Cheng, X Zhou, H Wu, B Zhang - Heliyon, 2024 - cell.com
Objective This study aimed to investigate the mechanism of Tu Fu Ling in treating
Alzheimer's disease (AD) using network pharmacology and molecular docking. Methods …
Alzheimer's disease (AD) using network pharmacology and molecular docking. Methods …
Exploration of Type III effector Xanthomonas outer protein Q (XopQ) inhibitor from Picrasma quassioides as an antibacterial agent using chemoinformatics analysis
PD Revanasiddappa, HG Gowtham, C GS… - PloS one, 2024 - journals.plos.org
The present study was focused on exploring the efficient inhibitors of closed state (form) of
type III effector Xanthomonas outer protein Q (XopQ)(PDB: 4P5F) from the 44 …
type III effector Xanthomonas outer protein Q (XopQ)(PDB: 4P5F) from the 44 …
Discovery of New 2-Phenylamino-3-acyl-1, 4-naphthoquinones as Inhibitors of Cancer Cells Proliferation: Searching for Intra-Cellular Targets Playing a Role in …
J Benites, JA Valderrama, Á Contreras, C Enríquez… - Molecules, 2023 - mdpi.com
A series of 2-phenylamino-3-acyl-1, 4-naphtoquinones were evaluated regarding their in
vitro antiproliferative activities using DU-145, MCF-7 and T24 cancer cells. Such activities …
vitro antiproliferative activities using DU-145, MCF-7 and T24 cancer cells. Such activities …
A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis in mice via binding and relocating acetyl-coA carboxylase
Y Lin, M Yang, L Huang, F Yang, J Fan, Y Qiang… - Cell Reports, 2023 - cell.com
Increased de novo lipogenesis (DNL) is a major feature of nonalcoholic steatohepatitis
(NASH). None of the drugs targeting the catalytic activity of acetyl-CoA carboxylase (ACC) …
(NASH). None of the drugs targeting the catalytic activity of acetyl-CoA carboxylase (ACC) …