W Jiao, Y Fan, NJ Blackmore, EJ Parker - Journal of Biological Chemistry, 2020 - ASBMB
Allostery exploits the conformational dynamics of enzymes by triggering a shift in population ensembles toward functionally distinct conformational or dynamic states. Allostery …
Y Bai, W Jiao, J Vörster, EJ Parker - Journal of Biological Chemistry, 2023 - ASBMB
α-Isopropylmalate synthase (IPMS) catalyzes the first step in leucine (Leu) biosynthesis and is allosterically regulated by the pathway end product, Leu. IPMS is a dimeric enzyme with …
Intricate systems of regulation at many levels act to control enzyme rates to tune metabolism across biosynthetic pathways. Allostery is a ubiquitous regulatory mechanism for feedback …
Adenosine triphosphate phosphoribosyl transferase (ATP-PRT) catalyses the first committed step of the histidine biosynthetic pathway in archaea, bacteria, fungi, and plants. The …