Carbon metabolic adjustment in soybean nodules in response to phosphate limitation: A metabolite perspective

S Sulieman, M Abdelrahman, LSP Tran - Environmental and Experimental …, 2022 - Elsevier
The necessity to gain deep insights regarding the overall metabolic efficiency of soybean
functional acclimation to tackle phosphate (Pi) starvation has led us to discuss the current …

A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in Mycobacterium tuberculosis

W Jiao, Y Fan, NJ Blackmore, EJ Parker - Journal of Biological Chemistry, 2020 - ASBMB
Allostery exploits the conformational dynamics of enzymes by triggering a shift in population
ensembles toward functionally distinct conformational or dynamic states. Allostery …

Conformational interdomain flexibility in a bacterial α-isopropylmalate synthase is necessary for leucine biosynthesis

Y Bai, W Jiao, J Vörster, EJ Parker - Journal of Biological Chemistry, 2023 - ASBMB
α-Isopropylmalate synthase (IPMS) catalyzes the first step in leucine (Leu) biosynthesis and
is allosterically regulated by the pathway end product, Leu. IPMS is a dimeric enzyme with …

Understanding enzymatic mechanism and allostery using macromolecular rate theory

EK Grout - 2022 - researchcommons.waikato.ac.nz
Intricate systems of regulation at many levels act to control enzyme rates to tune metabolism
across biosynthetic pathways. Allostery is a ubiquitous regulatory mechanism for feedback …

Exploring the Evolution and Function of the first Enzyme in Histidine Biosynthesis

P Khajeaian - 2022 - openaccess.wgtn.ac.nz
Adenosine triphosphate phosphoribosyl transferase (ATP-PRT) catalyses the first committed
step of the histidine biosynthetic pathway in archaea, bacteria, fungi, and plants. The …