Intrinsically disordered proteins (IDPs) lack stable tertiary and/or secondary structures under
physiological conditions in vitro. They are highly abundant in nature and their functional …

▪ Abstract Prion diseases are transmissible neurodegenerative conditions that include
Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform encephalopathy (BSE) …

Mammalian prions propagate as distinct strains and are composed of multichain assemblies
of misfolded host-encoded prion protein (PrP). Here, we present a near-atomic resolution …

Background Human prion diseases, including Creutzfeldt–Jakob disease (CJD), are rapidly
progressive, invariably fatal neurodegenerative conditions with no effective therapies. Their …

Recent reports give strong support to the idea that amyloid fibril formation and the
subsequent development of protein deposition diseases originate from conformational …

Prions are notorious protein-only infectious agents that cause invariably fatal brain diseases
following silent incubation periods that can span a lifetime. These diseases can arise …

The fibrillization of peptides is relevant to many diseases based on the deposition of
amyloids. The formation of fibrils is being intensively studied, especially in terms of …

We present a method for predicting the regions of the sequences of peptides and proteins
that are most important in promoting their aggregation and amyloid formation. The method …

Although a functional role in copper binding has been suggested for the prion protein,
evidence for binding at affinities characteristic of authentic metal-binding proteins has been …

▪ Abstract The prion hypothesis proposes that proteins can act as infectious agents.
Originally formulated to explain transmissible spongiform encephalopathies (TSEs), the …