Therapeutic ultrasound strategies that harness the mechanical activity of cavitation nuclei for
beneficial tissue bio-effects are actively under development. The mechanical oscillations of …

Conventional cancer chemotherapies often exhibit insufficient therapeutic outcomes and
dose-limiting toxicity. Therefore, there is a need for novel therapeutics and formulations with …

After the protocol-related indecisive clinical trial of Oxygent, a perfluorooctylbromide/
phospholipid nanoemulsion, in cardiac surgery, that often unduly assigned the observed …

At present, cancer is one of the leading causes of death worldwide. Treatment failure
remains one of the prime hurdles in cancer treatment due to the metastatic nature of cancer …

Introduction Delivering sufficient therapeutics at the target site without off-target effects is a
major goal of drug delivery technology innovation. Among the established methods …

The use of ultrasound and microbubbles to enhance therapeutic efficacy (sonoporation) has
shown great promise in cancer therapy from in vitro to ongoing clinical studies. The fastest …

Pancreatic ductal adenocarcinomas respond poorly to chemotherapy, in part due to the
dense tumor stroma that hinders drug delivery. Ultrasound (US) in combination with …

Acoustic nanodrops are designed to vaporize into ultrasound-responsive microbubbles,
which present certain challenges nonexistent for conventional nanoemulsions. The …

The use of ultrasound (US) and microbubbles (MB), usually referred to as sonoporation, has
great potential to increase the efficacy of chemotherapy. However, the molecular …

Introduction Acoustic cluster therapy (ACT) comprises co-administration of a formulation
containing microbubble/microdroplet clusters (PS101), together with a regular medicinal …