Abstract Die Entwicklung und Umsetzung von Kaskadenreaktionen hat zu beachtlichen
neuartigen, eleganten und effizienten Synthesestrategien geführt. Als besonders …

The advent of organic synthesis and the understanding of the molecule as they occurred in
the nineteenth century and were refined in the twentieth century constitute two of the most …

1, 2-Carbon atom rearrangement has been broadly applied as a guiding strategy in complex
molecule assembly. As it entails the carbon–carbon or carbon–heteroatom bond migration …

Zaragozic acid A (1) is a potent cholesterol lowering, polyketide natural product made by
various filamentous fungi. The reconstitution of enzymes responsible for the initial steps of …

A highly stereoselective organocatalytic one-pot protocol for the formal alkynylation and
alkenylation of α, β-unsaturated aldehydes using novel chemistry based on β-keto …

Zaragozic acid C (1) was isolated as a potent squalene synthase inhibitor. The 2, 8-
dioxabicyclo [3.2. 1] octane core of 1 is decorated with the three hydroxycarbonyl (C3, 4, 5) …

The total synthesis of (−)-borrelidin (treponemycin), a structurally distinct 18-membered
macrolide antibiotic, has been achieved. It was isolated as the crystalline benzene solvate …

This Perspective describes the discovery and development of silyl glyoxylates, a new family
of conjunctive reagents for use in multicomponent coupling reactions. The selection of the …

Despite the prevalence of repeating subunits in chiral natural products, stereocontrolled
oligomerization is a largely unexplored strategy for construction of carbon skeletal …

A facile and practical methodology for the synthesis of synthetically useful diarylmethanol‐
based 1, 4‐diols and enantiomerically pure BINOL‐derived diols with axial and sp3‐central …