Diabetes is one of the most prevalent cardiometabolic disorders on the planet. Type 1
diabetes accounts for only a minority of all cases (recently estimated to be~ 2% globally); …

Adult-onset autoimmune (AOA) diabetes pathophysiology starts with immune changes,
followed by dysglycaemia and overt disease. AOA diabetes can occur as classic type 1 …

Latent autoimmune diabetes of adults (LADA) is typically defined as a new diabetes
diagnosis after 35 years of age, presenting with clinical features of type 2 diabetes, in whom …

Type 2 diabetes (T2D) is characterized by a progressive status of chronic, low-grade
inflammation (LGI) that accompanies the whole trajectory of the disease, from its inception to …

Autoimmune diabetes is a heterogeneous disease which can arise at any age. Subjects with
adult-onset autoimmune diabetes who do not necessitate insulin-therapy for at least 6 …

As the heterogeneity of diabetes is becoming increasingly clear, opportunities arise for more
accurate assessment of factors influencing disease onset, which may lead to more efficient …

Beta cells adapt their function to respond to fluctuating glucose concentrations and variable
insulin demand. The highly specialized beta cells have well-established endoplasmic …

Abstract Bardet–Biedl Syndrome (BBS) is a pleiotropic genetic disease caused by the
dysfunction of primary cilia. The immune system of patients with ciliopathies has not been …

Latent autoimmune diabetes in adults (LADA) is a heterogeneous disease characterized by
a less intensive autoimmune process and a broad clinical phenotype compared to classical …

Diagnosis and management of type 1 diabetes (T1D) have remained largely unchanged for
the last several years. The management of the disease remains primarily focused on its …