Acute myocardial infarction (AMI) and the heart failure (HF) that often follows are among the
leading causes of death and disability worldwide. As such, new treatments are needed to …

Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …

Abnormal expression of proteins, including catalytic and expression dysfunction, is directly
related to the development of various diseases in living organisms. Reactive oxygen species …

Simple Summary The lens organ of the eye and muscle tissue exist at opposite ends of the
metabolic spectrum. Lens is metabolically quiescent using little energy, while muscle has …

Abstract Purpose of Review Myocardial metabolism is intricately linked to cardiac function.
Perturbations of cardiac energy metabolism result in an energy-starved heart and the …

Adenosine triphosphate is the present energy currency in the body, and is used in various
cellular and indispensable processes for the maintenance of cell homeostasis. The …

Background Creatine supplementation is known to exert an effect by increasing strength in
high intensity and short duration exercises. There is a hypothesis which suggests that …

Creatine is a key player in heart contraction and energy metabolism. Creatine
supplementation (throughout the paper, only supplementation with creatine monohydrate …

The energy starvation hypothesis proposes that maladaptive metabolic remodeling
antedates, initiates, and maintains adverse contractile dysfunction in heart failure (HF) …

Phosphocreatine (PCr) plays an important role in the energy metabolism of the heart and a
decrease in its intracellular concentration results in alteration of myocardium energetics and …