Fluorine does not belong to the pool of chemical elements that nature uses to build organic
matter. However, chemists have exploited the unique properties of fluorine and produced …

Fluorine-containing amino acids are becoming increasingly prominent in new drugs due to
two general trends in the modern pharmaceutical industry. Firstly, the growing acceptance of …

Eleven new fluorine-containing FDA-approved drugs have been profiled and details of their
discovery and preparation are discussed. Therapeutic areas include schizophrenia …

The two main strategies for enzyme engineering, directed evolution and rational design,
have found widespread applications in improving the intrinsic activities of proteins. Although …

The radical 1, 2-difunctionalization reaction of alkynes has evolved into a versatile approach
to multisubstituted alkylenes. However, robust catalytic strategies to perform carboamination …

Fluorine atoms confer desirable biophysical, chemical, and biological properties to
peptides/proteins by participating in various intermolecular interactions with their …

The site-selective modification of amino acids, peptides, and proteins has always been an
intensive topic in organic synthesis, medicinal chemistry, and chemical biology due to the …

Efficient methods for the dicarbofuntionalization of the cyclic alkenes 2‐pyrroline and 2‐
azetine are limited. Particularly, the dicarbofunctionalization of endocyclic enecarbamates to …

Two radical-based approaches have been developed to effect the trifluoromethylation of aryl
C–H bonds in native peptides either using stoichiometric oxidant or visible light photoredox …

Stereochemically defined organofluorine compounds are vital to drug discovery and many
applicable catalytic strategies have been introduced for accessing these entities …