Many protein species produced in recombinant bacteria aggregate as insoluble protein
clusters named inclusion bodies (IBs). IBs are discarded from further processing or are …

Both conventional and innovative biomedical approaches require cost-effective protein
drugs with high therapeutic potency, improved bioavailability, biocompatibility, stability and …

Background Redox-cofactor balancing constrains product yields in anaerobic fermentation
processes. This challenge is exemplified by the formation of glycerol as major by-product in …

Insufficient availability of molecular chaperones is observed as a major bottleneck for proper
protein folding in recombinant protein production. Therefore, co-production of selected sets …

Proteins are synthesized in heterologous systems because of the impossibility to obtain
satisfactory yields from natural sources. The production of soluble and functional …

The baculovirus expression vector system (BEVS) is a versatile and powerful platform for
protein expression in insect cells. With the ability to approach similar post-translational …

An increasing number of both prokaryotic and eukaryotic cell types are being adapted as
platforms for recombinant protein production. The overproduction of proteins in such …

The present disclosure identifies pathways, mechanisms, systems and methods to confer
chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols …

Bacterial Inclusion Bodies (IBs) are amyloidal protein deposits that functionally mimic
secretory granules from the endocrine system. When formed by therapeutically relevant …

(52) US Cl. CPC................ CI2N 15/52 (2013.01); C12N 15/74 (2013.01); C12N 1/20
(2013.01); C12P 7/16 (2013.01); CI2P 7/40 (2013.01)(57) ABSTRACT The present …