Current estimates suggest that nearly half a billion people worldwide are affected by hearing
loss. Because of the major psychological, social, economic, and health ramifications …

Non-mammalian vertebrates can restore their auditory and vestibular hair cells naturally by
triggering the regeneration of adjacent supporting cells. The transcription factor ATOH1 is a …

The exploration of three-dimensional chromatin interaction and organization provides
insight into mechanisms underlying gene regulation, cell differentiation and disease …

DNA methylation is an important regulator of gene transcription. WGBS is the gold-standard
approach for base-pair resolution quantitative of DNA methylation. It requires high …

Meniere Disease (MD) is a multifactorial disorder of the inner ear characterized by vertigo
attacks associated with sensorineural hearing loss and tinnitus with a significant heritability …

The age of sequencing has provided unprecedented insights into the human genome. The
coding region of the genome comprises nearly 20,000 genes, of which approximately 4000 …

The USH2A variant c. 2276 G> T (p.(Cys759Phe)) has been described by many authors as a
frequent cause of autosomal recessive retinitis pigmentosa (arRP). However, this is in …

Background Methylation at cytosines (mCG) is a well-known regulator of gene expression,
but its requirements for cellular differentiation have yet to be fully elucidated. A well-studied …

DNA methylation is an important epigenetic mechanism for gene regulation. The
conventional view of DNA methylation is that DNA methylation could disrupt protein-DNA …

Acinetobacter haemolyticus (A. haemolyticus) is a significant Acinetobacter pathogen, and
the resistance of A. haemolyticus continues to rise due to abuse of antibiotics and the …