Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity

A de Morree, TA Rando - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Systems and synthetic microRNA biology: from biogenesis to disease pathogenesis

H Matsuyama, HI Suzuki - International journal of molecular sciences, 2019 - mdpi.com
MicroRNAs (miRNAs) are approximately 22-nucleotide-long, small non-coding RNAs that
post-transcriptionally regulate gene expression. The biogenesis of miRNAs involves multiple …

Stem-cell aging and pathways to precancer evolution

CHM Jamieson, IL Weissman - New England Journal of Medicine, 2023 - Mass Medical Soc
Stem-Cell Aging and Pathways to Precancer Evolution | New England Journal of Medicine Skip
to main content The New England Journal of Medicine homepage Advanced Search SEARCH …

Epitranscriptomics and epiproteomics in cancer drug resistance: therapeutic implications

H Song, D Liu, S Dong, L Zeng, Z Wu, P Zhao… - Signal transduction and …, 2020 - nature.com
Drug resistance is a major hurdle in cancer treatment and a key cause of poor prognosis.
Epitranscriptomics and epiproteomics are crucial in cell proliferation, migration, invasion …

3′ UTR heterogeneity and cancer progression

JJ Chan, H Tabatabaeian, Y Tay - Trends in Cell Biology, 2023 - cell.com
The majority of human mRNAs generate alternative 3′ untranslated regions (UTRs)
through various processes, including RNA modifications such as RNA editing, m 6 A …

ADAR1 and its implications in cancer development and treatment

AR Baker, FJ Slack - Trends in Genetics, 2022 - cell.com
The family of adenosine deaminases acting on RNA (ADARs) regulates global gene
expression output by catalyzing adenosine-to-inosine (A-to-I) editing of double-stranded …

Reversal of malignant ADAR1 splice isoform switching with Rebecsinib

LA Crews, W Ma, L Ladel, J Pham, L Balaian, SK Steel… - Cell Stem Cell, 2023 - cell.com
Adenosine deaminase acting on RNA1 (ADAR1) preserves genomic integrity by preventing
retroviral integration and retrotransposition during stress responses. However, inflammatory …

Low RNA stability signifies increased post-transcriptional regulation of cell identity genes

Y Li, Y Yi, J Lv, X Gao, Y Yu, SS Babu… - Nucleic acids …, 2023 - academic.oup.com
Cell identity genes are distinct from other genes with respect to the epigenetic mechanisms
to activate their transcription, eg by super-enhancers and broad H3K4me3 domains …

Cellular RNA surveillance in health and disease

SL Wolin, LE Maquat - Science, 2019 - science.org
The numerous quality control pathways that target defective ribonucleic acids (RNAs) for
degradation play key roles in shaping mammalian transcriptomes and preventing disease …

Human MYC G-quadruplex: From discovery to a cancer therapeutic target

W Wang, S Hu, Y Gu, Y Yan, DB Stovall, D Li… - Biochimica et Biophysica …, 2020 - Elsevier
Overexpression of the MYC oncogene is a molecular hallmark of both cancer initiation and
progression. Targeting MYC is a logical and effective cancer therapeutic strategy. A special …