Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that involves
dysregulation of many cellular and molecular processes. It is notoriously difficult to develop …

Abstract Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …

Accumulation and aggregation of amyloid-β (Aβ) in the brain is an initiating step in the
pathogenesis of Alzheimer's disease (AD). The ε4 allele of apolipoprotein E (apoE) gene is …

The neurological deterioration associated with Alzheimer's disease (AD), involving
accumulation of amyloid-beta peptides and neurofibrillary tangles, is associated with evident …

Apolipoprotein E (APOE) is a 299-aminoacid protein encoded by the APOE gene. Three
common polymorphisms in the APOE gene, ɛ2, ɛ3, and ɛ4, result in a single aminoacid …

The ɛ4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's
disease (AD). Although there have been numerous studies attempting to elucidate the …

Neuroinflammation is a common feature in neurodegenerative diseases, modulated by the
Alzheimer's disease risk factor, apolipoprotein E (APOE). In the brain, apoE protein is …

Alzheimer's disease (AD) is an immutable neurodegenerative disease featured by the two
hallmark brain pathologies that are the extracellular amyloid ß (Aß) and intraneuronal tau …

Glia play active and vital roles in the CNS, including regulation of brain development,
maintenance of cellular homeostasis and reparative responses to acute and chronic …

Acute, subchronic, or chronic exposures to particulate matter (PM) and pollutant gases affect
people in urban areas and those exposed to fires, disasters, and wars. Respiratory tract …