The genetic, functional or compositional heterogeneity of healthy and diseased tissues
presents major challenges in drug discovery and development. Such heterogeneity hinders …

Continuous analysis of single cells, over several cell divisions and for up to weeks at a time,
is crucial to deciphering rare, dynamic and heterogeneous cell responses, which would …

Live single-cell mass spectrometry (live MS) provides a mass spectrum that shows
thousands of metabolite peaks from a single live plant cell within minutes. By using an …

Cells must respond sensitively to time-varying inputs in complex signaling environments. To
understand how signaling networks process dynamic inputs into gene expression outputs …

Cells receive time-varying signals from the environment and generate functional responses
by secreting their own signaling molecules. Characterizing dynamic input-output …

Biochemical analysis is crucial in understanding mechanism of life activities and giving
biological insights into life process. With inherent merits in flexible design, microscale of …

We report a reliable full-angle tomographic phase microscopy (FA-TPM) method for flowing
quasi-spherical cells along microfluidic channels. This method lies in a completely passive …

Cells receive a wide range of dynamic signaling inputs during immune regulation, but how
gene regulatory networks measure such dynamic inputs is not well understood. Here, we …

Silicon is the gold standard for information storage systems. The exponential generation of
digital information will exhaust the global supply of refined silicon. Therefore, investing in …

Infected cells communicate through secreted signaling molecules like cytokines, which carry
information about pathogens. How differences in cytokine secretion affect inflammatory …