Enantioselective synthesis with small-molecule chiral hydrogen-bond donors has emerged
as a frontier of research in the field of asymmetric catalysis. Organic chemists have …

Heterocycles are an extraordinarily important class of compounds, making up more than half
of all known organic compounds. Heterocycles are present in a wide variety of drugs, most …

Over the last decades, excellent computational chemistry tools have been developed.
Integrating them into a single platform with enhanced accessibility could help reaching their …

Large language models (LLMs) have shown strong performance in tasks across domains
but struggle with chemistry-related problems. These models also lack access to external …

Chalcogen bonding is the non‐covalent interaction between Lewis acidic chalcogen
substituents and Lewis bases. Herein, we present the first application of dicationic tellurium …

The asymmetric Friedel–Crafts reaction is one of the most powerful methods to synthesize
optically active aromatic compounds. Particularly, the Friedel–Crafts alkylation of arenes …

The desire for new synthetic methodologies for the rapid construction of enantiomerically
pure substituted indole has been a fruitful driving force for chemical research in the last few …

The assembly of architecturally complex alkaloids embedding the indole nucleus is of
paramount importance for the target oriented synthesis of biologically active molecules. 1 A …

Particular success has been achieved in the synthesis of new products and in processes
since the twelve principles of “green chemistry” were formulated in the 1990s. These …

Charles Friedel (1832-1899) started a dual scientific career and spent several years of
activities divided between mineralogy at Ecole des Mines and chemical research. 1 The …