Characterizing micro-to-millisecond chemical exchange in nucleic acids using off-resonance R1ρ relaxation dispersion
This review describes off-resonance R 1ρ relaxation dispersion NMR methods for
characterizing microsecond-to-millisecond chemical exchange in uniformly 13 C/15 N …
characterizing microsecond-to-millisecond chemical exchange in uniformly 13 C/15 N …
NMR studies of aromatic ring flips to probe conformational fluctuations in proteins
M Akke, U Weininger - The Journal of Physical Chemistry B, 2023 - ACS Publications
Aromatic residues form a significant part of the protein core, where they make tight
interactions with multiple surrounding side chains. Despite the dense packing of internal …
interactions with multiple surrounding side chains. Despite the dense packing of internal …
Chemical exchange
AG Palmer III, H Koss - Methods in enzymology, 2019 - Elsevier
The phenomenon of chemical or conformational exchange in NMR spectroscopy has
enabled detailed characterization of time-dependent aspects of biomolecular function …
enabled detailed characterization of time-dependent aspects of biomolecular function …
A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions
B Liu, H Shi, A Rangadurai, F Nussbaumer… - Nature …, 2021 - nature.com
ABSTRACT N 6-methyladenosine (m6A) is a post-transcriptional modification that controls
gene expression by recruiting proteins to RNA sites. The modification also slows …
gene expression by recruiting proteins to RNA sites. The modification also slows …
Discrete-state stochastic kinetic models for target DNA search by proteins: Theory and experimental applications
J Iwahara, AB Kolomeisky - Biophysical chemistry, 2021 - Elsevier
To perform their functions, transcription factors and DNA-repair/modifying enzymes
randomly search DNA in order to locate their specific targets on DNA. Discrete-state …
randomly search DNA in order to locate their specific targets on DNA. Discrete-state …
Recent advances in solid-state relaxation dispersion techniques
P Rovo - Solid State Nuclear Magnetic Resonance, 2020 - Elsevier
This review describes two rotating-frame (R 1 ρ) relaxation dispersion methods, namely the
Bloch-McConnell Relaxation Dispersion and the Near-rotary Resonance Relaxation …
Bloch-McConnell Relaxation Dispersion and the Near-rotary Resonance Relaxation …
Rescuing off-equilibrium simulation data through dynamic experimental data with dynAMMo
Long-timescale behavior of proteins is fundamental to many biological processes. Molecular
dynamics (MD) simulations and biophysical experiments are often used to study protein …
dynamics (MD) simulations and biophysical experiments are often used to study protein …
A suite of 19F based relaxation dispersion experiments to assess biomolecular motions
JH Overbeck, W Kremer, R Sprangers - Journal of biomolecular NMR, 2020 - Springer
Proteins and nucleic acids are highly dynamic bio-molecules that can populate a variety of
conformational states. NMR relaxation dispersion (RD) methods are uniquely suited to …
conformational states. NMR relaxation dispersion (RD) methods are uniquely suited to …
Dynamic basis for dA• dGTP and dA• d8OGTP misincorporation via Hoogsteen base pairs
Replicative errors contribute to the genetic diversity needed for evolution but in high
frequency can lead to genomic instability. Here, we show that DNA dynamics determine the …
frequency can lead to genomic instability. Here, we show that DNA dynamics determine the …
The A39G FF domain folds on a volcano-shaped free energy surface via separate pathways
Conformational dynamics play critical roles in protein folding, misfolding, function,
misfunction, and aggregation. While detecting and studying the different conformational …
misfunction, and aggregation. While detecting and studying the different conformational …