Association between genetic variants and diabetes mellitus in Iranian populations: a systematic review of observational studies

M Khodaeian, S Enayati… - Journal of diabetes …, 2015 - Wiley Online Library
Introduction. Diabetes mellitus as the most prevalent metabolic disease is a multifactorial
disease which is influenced by environmental and genetic factors. In this systematic review …

Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population

I Akhlaghipour, AR Bina, MR Mogharrabi, A Fanoodi… - Human Genomics, 2022 - Springer
Diabetes is a chronic metabolic disorder that leads to the dysfunction of various tissues and
organs, including eyes, kidneys, and cardiovascular system. According to the World Health …

[HTML][HTML] Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism

G Geoghegan, J Simcox, MM Seldin, TJ Parnell… - Molecular …, 2019 - Elsevier
Abstract Objective Activation of the Wnt-signaling pathway is known to inhibit differentiation
in adipocytes. However, there is a gap in our understanding of the transcriptional network …

Association of transcription factor 7-like 2 rs12255372 polymorphism with susceptibility of type 2 diabetes mellitus in Bangladeshi population

N Barman, M Atiqul Haque, M Firoz… - Molecular Genetics and …, 2023 - Springer
Polymorphism of transcription factor 7-like 2 (TCF7L2) has a link with type 2 diabetes
mellitus (T2DM) through β cell dysfunction that causes defect in blood glucose homeostasis …

A critical review on therapeutic approaches of CRISPR-Cas9 in diabetes mellitus

J Bora, A Dey, AR Lyngdoh, A Dhasmana… - Naunyn-Schmiedeberg's …, 2023 - Springer
Diabetes mellitus (DM) is a common metabolic disorder caused mainly by combining two
primary factors, which are (1) defects in insulin production by the pancreatic β-cells and (2) …

Association of TCF7L2 gene polymorphisms with T2DM in the population of Hyderabad, India

K Uma Jyothi, M Jayaraj, KS Subburaj, KJ Prasad… - PLoS …, 2013 - journals.plos.org
We attempt to evaluate the nature of association of TCF7L2 gene variants with T2DM, for the
first time in the population of Hyderabad, which is considered to be diabetic capital of India. It …

SLC30A8, CDKAL1, TCF7L2, KCNQ1 and IGF2BP2 are Associated with Type 2 Diabetes Mellitus in Iranian Patients

K Vatankhah Yazdi, SM Kalantar… - Diabetes, Metabolic …, 2020 - Taylor & Francis
Background Type 2 diabetes mellitus (T2DM) is a serious public health issue with
significantly increasing rates across the world. The genome-wide association studies …

[PDF][PDF] Association of rs7903146, rs12255372, and rs290487 polymorphisms in TCF7L2 gene with type 2 diabetes in an Iranian Kurdish ethnic group

S Shokouhi, A Delpisheh, K Haghani, M Mahdizadeh… - Clin Lab, 2014 - core.ac.uk
SUMMARY Background: Single nucleotide polymorphisms (SNPs) within the transcription
factor 7-like 2 (TCF7L2) gene are well known risk variants for type 2 diabetes mellitus …

Work-family conflict and sleep disturbance: the Malaysian working women study

S Aazami, M Mozafari, K Shamsuddin, S Akmal - Industrial health, 2016 - jstage.jst.go.jp
This study aimed at assessing effect of the four dimensions of work-family conflicts (strain
and time-based work interference into family and family interference into work) on sleep …

[HTML][HTML] Association of rs12255372 in theTCF7L2 gene with type 2 diabetes mellitus: a meta-analysis

J Wang, J Zhang, L Li, Y Wang, Q Wang… - Brazilian Journal of …, 2013 - SciELO Brasil
Our objective was to evaluate the association of rs12255372 in theTCF7L2 gene with type 2
diabetes mellitus (T2DM) in the world population. We carried out a survey of the literature …