The gut microbiota refers to the trillions of microorganisms residing in the intestine and is
integral in multiple physiological processes of the host. Recent research has shown that gut …

The development of obesity and insulin resistance has been extensively studied in the last
decades, but the mechanisms underlying these alterations are still not completely …

Obesity is characterized by the development of a low-grade chronic inflammatory state in
different metabolic tissues including adipose tissue and liver. This inflammation develops in …

Pathogen and nutrient response pathways are evolutionarily conserved and highly
integrated to regulate metabolic and immune homeostasis. Excessive nutrients can be …

NOD1 {nucleotide-binding oligomerization domain 1; NLRC [NOD-LRR (leucine-rich repeat)
family with CARD (caspase recruitment domain) 1]} and NOD2 (NLRC2) are among the …

The human gut is the natural habitat for trillions of microorganisms, known as the gut
microbiota, which play indispensable roles in maintaining host health. Defining the …

The study of the intersection of immunology and metabolism is a growing field fueled by the
increased prevalence of obesity-associated pathologies. Importantly, the capacity of the …

Gestational diabetes mellitus (GDM) imposes serious short-and long-term health problems
for mother and baby. An effective therapeutic that can reduce the incidence of GDM and …

Background Obesity is associated with macrophage infiltration of adipose tissue. These
inflammatory cells affect adipocytes not only by classical cytokines but also by the secreted …

Gut microbes comprise a high density, biologically active community that lies at the interface
of an animal with its nutritional environment. Consequently their activity profoundly …