Sensitivity analysis methods in the biomedical sciences

G Qian, A Mahdi - Mathematical biosciences, 2020 - Elsevier
Sensitivity analysis is an important part of a mathematical modeller's toolbox for model
analysis. In this review paper, we describe the most frequently used sensitivity techniques …

The contribution of insects to global forest deadwood decomposition

S Seibold, W Rammer, T Hothorn, R Seidl, MD Ulyshen… - Nature, 2021 - nature.com
The amount of carbon stored in deadwood is equivalent to about 8 per cent of the global
forest carbon stocks. The decomposition of deadwood is largely governed by climate,,–with …

Imaging and biophysical modelling of thrombogenic mechanisms in atrial fibrillation and stroke

A Qureshi, GYH Lip, DA Nordsletten… - Frontiers in …, 2023 - frontiersin.org
Atrial fibrillation (AF) underlies almost one third of all ischaemic strokes, with the left atrial
appendage (LAA) identified as the primary thromboembolic source. Current stroke risk …

Multi-method global sensitivity analysis of mathematical models

A Dela, B Shtylla, L de Pillis - Journal of Theoretical Biology, 2022 - Elsevier
Increasingly-sophisticated parameter-sensitivity analysis techniques continue to be
developed, and each technique comes with its own set of advantages and disadvantages …

Modelling of thrombus formation using smoothed particle hydrodynamics method

A Monteleone, A Viola, E Napoli, G Burriesci - Plos one, 2023 - journals.plos.org
In this paper a novel model, based on the smoothed particle hydrodynamics (SPH) method,
is proposed to simulate thrombus formation. This describes the main phases of the …

Inhibition of platelet-surface-bound proteins during coagulation under flow I: TFPI

K Miyazawa, AL Fogelson, K Leiderman - Biophysical journal, 2023 - cell.com
Blood coagulation is a self-repair process regulated by activated platelet surfaces, clotting
factors, and inhibitors. Tissue factor pathway inhibitor (TFPI) is one such inhibitor, well …

[HTML][HTML] A mathematical model of coagulation under flow identifies factor V as a modifier of thrombin generation in hemophilia A

KG Link, MT Stobb, MG Sorrells, M Bortot… - Journal of Thrombosis …, 2020 - Elsevier
Background The variability in bleeding patterns among individuals with hemophilia A, who
have similar factor VIII (FVIII) levels, is significant and the origins are unknown. Objective To …

Performance of rainfall–runoff models in reproducing hydrological extremes: a case of the River Malaba sub-catchment

A Mubialiwo, A Abebe, C Onyutha - SN Applied Sciences, 2021 - Springer
Abstract Daily River Malaba flows recorded from 1999 to 2016 were modelled using seven
lumped conceptual rainfall–runoff models including AWBM, SACRAMENTO, TANK …

Sensitivity and robustness of spatially dependent thrombin generation and fibrin clot propagation

AD Kuprash, AM Shibeko, R Vijay, SC Nair… - Biophysical …, 2018 - cell.com
Blood coagulation is a delicately regulated space-and time-dependent process that leads to
the formation of fibrin clots preventing blood loss upon vascular injury. The sensitivity of the …

[HTML][HTML] Advanced sensitivity analysis of the impact of the temporal distribution and intensity of rainfall on hydrograph parameters in urban catchments

F Fatone, B Szeląg, A Kiczko, D Majerek… - Hydrology and Earth …, 2021 - hess.copernicus.org
Abstract Knowledge of the variability of the hydrograph of outflow from urban catchments is
highly important for measurements and evaluation of the operation of sewer networks …