The fatty acid composition of photoreceptor outer segment (POS) phospholipids diverges
from other membranes, being highly enriched in polyunsaturated fatty acids (PUFAs). The …

The important roles of mitochondrial function and dysfunction in the process of
neurodegeneration are widely acknowledged. Retinal ganglion cells (RGCs) appear to be a …

Retinal pigment epithelium (RPE) cells have to phagocytose shed photoreceptor outer
segments (POS) on a daily basis over the lifetime of an organism, but the mechanisms …

Age-related macular degeneration (AMD) is a major leading cause of irreversible visual
impairment in the world with limited therapeutic interventions. Histological, biochemical …

Transmembrane proteins (TMEMs) are integral proteins that span biological membranes.
TMEMs function as cellular membrane gates by modifying their conformation to control the …

Abstract Transmembrane protein 135 (TMEM135) is thought to participate in the cellular
response to increased intracellular lipids yet no defined molecular function for TMEM135 in …

Aging is a significant factor in the development of age-related diseases but how aging
disrupts cellular homeostasis to cause age-related retinal disease is unknown. Here, we …

Fluorescent proteins (FPs) have been widely used to investigate cellular and molecular
interactions and trace biological events in many applications. Some of the FPs have been …

Aging is the most significant risk factor for age-related diseases in general, which is true for
age-related diseases in the eye including age-related macular degeneration (AMD) …

Age-related macular degeneration (AMD) is a debilitating retinal disorder in aging
populations. It is widely believed that dysfunction of the retinal pigmented epithelium (RPE) …