Targeting ferroptosis in acute kidney injury

L Ni, C Yuan, X Wu - Cell Death & Disease, 2022 - nature.com
Acute kidney injury (AKI) is a major public health problem with high incidence and mortality.
As a form of programmed cell death (PCD), ferroptosis could be considered as a process of …

Nrf2 and ferroptosis: a new research direction for neurodegenerative diseases

X Song, D Long - Frontiers in neuroscience, 2020 - frontiersin.org
Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of
intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which …

Mechanism of ferroptosis and its role in type 2 diabetes mellitus

W Sha, F Hu, Y Xi, Y Chu, S Bu - Journal of diabetes research, 2021 - Wiley Online Library
Ferroptosis is a novel form of nonapoptotic regulated cell death (RCD). It features iron‐
dependent lipid peroxide accumulation accompanied by inadequate redox enzymes …

The role of erastin in ferroptosis and its prospects in cancer therapy

Y Zhao, Y Li, R Zhang, F Wang, T Wang… - OncoTargets and …, 2020 - Taylor & Francis
Erastin was initially discovered as a small molecule compound that selectively kills tumor
cells expressing ST and RASV12 and was later widely investigated as an inducer of …

Ferroptosis, as the most enriched programmed cell death process in glioma, induces immunosuppression and immunotherapy resistance

T Liu, C Zhu, X Chen, G Guan, C Zou, S Shen… - Neuro …, 2022 - academic.oup.com
Background Immunosuppressive microenvironment is a major cause of immunotherapeutic
resistance in glioma. In addition to secreting compounds, tumor cells under programmed cell …

Myocardial ischemia/reperfusion injury: Mechanisms of injury and implications for management

J He, D Liu, L Zhao, D Zhou… - Experimental and …, 2022 - spandidos-publications.com
Myocardial infarction is one of the primary causes of mortality in patients with coronary heart
disease worldwide. Early treatment of acute myocardial infarction restores blood supply of …

CircIL4R facilitates the tumorigenesis and inhibits ferroptosis in hepatocellular carcinoma by regulating the miR‐541‐3p/GPX4 axis

Q Xu, L Zhou, G Yang, F Meng, Y Wan… - Cell biology …, 2020 - Wiley Online Library
Ferroptosis is a specific iron‐dependent cell death form that can induce the production of
lipid peroxide, but the roles of circular RNAs (circRNAs) in ferroptosis are completely …

Toward improved human health: Nrf2 plays a critical role in regulating ferroptosis

J Lu, Y Zhao, M Liu, J Lu, S Guan - Food & Function, 2021 - pubs.rsc.org
Ferroptosis is a recently defined type of regulated cell death caused by an excess iron-
dependent accumulation of lipid peroxides and is morphologically and biochemically distinct …

Heme-oxygenase-1 as a target for phthalate-induced cardiomyocytes ferroptosis

JX Wang, Y Zhao, MS Chen, H Zhang, JG Cui… - Environmental Pollution, 2023 - Elsevier
Phthalates as a large group of environmental pollutants are used primarily as plasticizers
and solvents, which have become a growing problem worldwide. Epidemiological results …

A novel circular RNA confers trastuzumab resistance in human epidermal growth factor receptor 2‐positive breast cancer through regulating ferroptosis

S Wang, Y Wang, Q Li, X Li… - Environmental Toxicology, 2022 - Wiley Online Library
HER2‐positive breast cancer is an aggressive subtype of breast cancer, characterized by
high malignancy and poor prognosis. Trastuzumab, the first HER2‐targeted monoclonal …