Rhesus monkeys for a nonhuman primate model of cytomegalovirus infections

HL Itell, A Kaur, JD Deere, PA Barry… - Current opinion in virology, 2017 - Elsevier
Highlights•Nonhuman primate (NHP) CMVs are most closely related to human CMV
(HCMV).•Rhesus CMV (RhCMV) bears numerous genomic and functional similarities to …

Animal models of congenital cytomegalovirus transmission: implications for vaccine development

HK Roark, JA Jenks, SR Permar… - The Journal of …, 2020 - academic.oup.com
Although cytomegaloviruses (CMVs) are species-specific, the study of nonhuman CMVs in
animal models can help to inform and direct research aimed at developing a human CMV …

Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation

CA Fielding, R Aicheler, RJ Stanton, ECY Wang… - PLoS …, 2014 - journals.plos.org
NKG2D plays a major role in controlling immune responses through the regulation of natural
killer (NK) cells, αβ and γδ T-cell function. This activating receptor recognizes eight distinct …

Human cytomegalovirus interleukin 10 homologs: facing the immune system

E Poole, TC Neves, MT Oliveira, J Sinclair… - Frontiers in Cellular …, 2020 - frontiersin.org
Human Cytomegalovirus (HCMV) can cause a variety of health disorders that can lead to
death in immunocompromised individuals and neonates. The HCMV lifecycle comprises …

Non-human primate models to investigate mechanisms of infection-associated fetal and pediatric injury, teratogenesis and stillbirth

M Li, A Brokaw, AM Furuta, B Coler… - Frontiers in …, 2021 - frontiersin.org
A wide array of pathogens has the potential to injure the fetus and induce teratogenesis, the
process by which mutations in fetal somatic cells lead to congenital malformations. Rubella …

Reevaluation of the coding potential and proteomic analysis of the BAC-derived rhesus cytomegalovirus strain 68-1

D Malouli, ES Nakayasu, K Viswanathan… - Journal of …, 2012 - Am Soc Microbiol
Cytomegaloviruses are highly host restricted, resulting in cospeciation with their hosts. As a
natural pathogen of rhesus macaques (RM), rhesus cytomegalovirus (RhCMV) has therefore …

Glycoprotein N of human cytomegalovirus protects the virus from neutralizing antibodies

B Kropff, C Burkhardt, J Schott, J Nentwich… - PLoS …, 2012 - journals.plos.org
Herpes viruses persist in the infected host and are transmitted between hosts in the
presence of a fully functional humoral immune response, suggesting that they can evade …

Cross-species rhesus cytomegalovirus infection of cynomolgus macaques

BJ Burwitz, D Malouli, BN Bimber, JS Reed… - PLoS …, 2016 - journals.plos.org
Cytomegaloviruses (CMV) are highly species-specific due to millennia of co-evolution and
adaptation to their host, with no successful experimental cross-species infection in primates …

A critical analysis of the cynomolgus macaque, Macaca fascicularis, as a model to test HIV-1/SIV vaccine efficacy

JM Antony, KS MacDonald - Vaccine, 2015 - Elsevier
The use of a number of non-rhesus macaque species, but especially cynomolgus macaques
as a model for HIV-1 vaccine development has increased in recent years. Cynomolgus …

A novel bat herpesvirus encodes homologues of major histocompatibility complex classes I and II, C-type lectin, and a unique family of immune-related genes

H Zhang, S Todd, M Tachedjian, JA Barr, M Luo… - Journal of …, 2012 - Am Soc Microbiol
Herpesviruses or herpesviral sequences have been identified in various bat species. Here,
we report the isolation, cell tropism, and complete genome sequence of a novel …