The pathogenesis of Alzheimer's disease is highly complex. While several pathologies
characterize this disease, amyloid plaques, composed of the β-amyloid peptide are hallmark …

Neurodegenerative diseases (NDs) are characterized by the aggregation of neurotoxic
proteins in the central nervous system. Aberrant protein accumulation in NDs is largely …

Deposition of amyloid β protein (Aβ) to form neuritic plaques in the brain is the pathological
hallmark of Alzheimer's disease (AD). Aβ is generated from sequential cleavages of the β …

Elevated levels of β-site APP cleaving enzyme 1 (BACE1) were found in the brain of some
sporadic Alzheimer's disease (AD) patients; however, the underlying mechanism is …

The proteasome has key roles in neuronal proteostasis, including the removal of misfolded
and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity …

Summary β-site APP cleaving enzyme-1 (BACE1), the rate-limiting enzyme for β-amyloid
(Aβ) production, is elevated in Alzheimer's disease (AD). Here, we show that energy …

Neuritic plaques in the brains are one of the pathological hallmarks of Alzheimer's disease
(AD). Amyloid β-protein (Aβ), the central component of neuritic plaques, is derived from β …

Resveratrol, a red wine polyphenol, is known to protect against cardiovascular diseases and
cancers, as well as to promote antiaging effects in numerous organisms. It also modulates …

β-Site amyloid precursor protein cleaving enzyme 1 (BACE1)(β-secretase) initiates
generation of β-amyloid (Aβ), which plays an early role in Alzheimer's disease (AD). BACE1 …

The ubiquitin-proteasome system (UPS) is a crucial protein degradation system in
eukaryotes. Herein, we will review advances in the understanding of the role of several …