Repurposing existing drugs for the treatment of COVID-19/SARS-CoV-2 infection: A review describing drug mechanisms of action
The outbreak of a novel coronavirus (SARS-CoV-2) has caused a major public health
concern across the globe. SARS-CoV-2 is the seventh coronavirus that is known to cause …
concern across the globe. SARS-CoV-2 is the seventh coronavirus that is known to cause …
The impact of matrix metalloproteinase-9 on the sequential steps of the metastatic process
G Barillari - International journal of molecular sciences, 2020 - mdpi.com
In industrialized countries, cancer is the second leading cause of death after cardiovascular
disease. Most cancer patients die because of metastases, which consist of the self …
disease. Most cancer patients die because of metastases, which consist of the self …
[HTML][HTML] A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the …
RE Kast, JA Boockvar, A Brüning, F Cappello… - Oncotarget, 2013 - ncbi.nlm.nih.gov
To improve prognosis in recurrent glioblastoma we developed a treatment protocol based
on a combination of drugs not traditionally thought of as cytotoxic chemotherapy agents but …
on a combination of drugs not traditionally thought of as cytotoxic chemotherapy agents but …
[HTML][HTML] CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline …
RE Kast, G Karpel-Massler, ME Halatsch - Oncotarget, 2014 - ncbi.nlm.nih.gov
CUSP9 treatment protocol for recurrent glioblastoma was published one year ago. We now
present a slight modification, designated CUSP9*. CUSP9* drugs-aprepitant, artesunate …
present a slight modification, designated CUSP9*. CUSP9* drugs-aprepitant, artesunate …
HPV-associated anal cancer in the HIV/AIDS patient
CCJ Wang, JM Palefsky - HIV/AIDS-Associated Viral Oncogenesis, 2019 - Springer
The prevalence of anal human papillomavirus (HPV) infection and anal high-grade
squamous intraepithelial lesion (HSIL) remain high among HIV-infected individuals on …
squamous intraepithelial lesion (HSIL) remain high among HIV-infected individuals on …
HIV‐protease inhibitors for the treatment of cancer: Repositioning HIV protease inhibitors while developing more potent NO‐hybridized derivatives?
D Maksimovic‐Ivanic, P Fagone… - … Journal of Cancer, 2017 - Wiley Online Library
The possible use of HIV protease inhibitors (HIV‐PI) as new therapeutic option for the
treatment of cancer primarily originated from their success in treating HIV‐related Kaposi's …
treatment of cancer primarily originated from their success in treating HIV‐related Kaposi's …
[HTML][HTML] Nelfinavir and other protease inhibitors in cancer: mechanisms involved in anticancer activity
T Koltai - F1000Research, 2015 - ncbi.nlm.nih.gov
Objective: To review the mechanisms of anti-cancer activity of nelfinavir and other protease
inhibitors (PIs) based on evidences reported in the published literature. Methods: We …
inhibitors (PIs) based on evidences reported in the published literature. Methods: We …
Nelfinavir, an HIV protease inhibitor, induces apoptosis and cell cycle arrest in human cervical cancer cells via the ROS-dependent mitochondrial pathway
T Xiang, L Du, P Pham, B Zhu, S Jiang - Cancer letters, 2015 - Elsevier
HIV protease inhibitors (HIV-PIs) are a class of antiretroviral drugs designed to target the
viral protease. Strikingly, these drugs have also been reported to possess antitumor effect. In …
viral protease. Strikingly, these drugs have also been reported to possess antitumor effect. In …
Molecular Mechanisms of HIV Protease Inhibitors Against HPV-Associated Cervical Cancer: Restoration of TP53 Tumour Suppressor Activities
Cervical cancer is a Human Papilloma virus-related disease, which is on the rise in a
number of countries, globally. Two essential oncogenes, E6 and E7, drive cell …
number of countries, globally. Two essential oncogenes, E6 and E7, drive cell …
HIV-1 protease inhibitors slow HPV16-driven cell proliferation through targeted depletion of viral E6 and E7 oncoproteins
S Park, A Auyeung, DL Lee, PF Lambert, EH Carchman… - Cancers, 2021 - mdpi.com
Simple Summary High-risk strains of human papillomavirus (HPV) such as HPV16 cause
anogenital and oropharyngeal cancers, with HPV-associated cervical cancer being the …
anogenital and oropharyngeal cancers, with HPV-associated cervical cancer being the …